3-Butyryl-4-(2-hydroxyanilino)-6-methyl-2H-pyran-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Butyryl-4-(2-hydroxyanilino)-6-methyl-2H-pyran-2-one
• 英文别名: 3-butanoyl-4-(2-hydroxyanilino)-6-methylpyran-2-one
• 化学式: C₁₆H₁₇NO₄
• mdl: MFCD05859684
• 分子量: 287.31
• InChiKey: ZDIYJQMKVQXCKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] ADMINISTRATION OF CALCIUM CHANNEL TRPC6 INHIBITORS USING BALLOONS, STENTS OR OTHER MEDICAL DEVICES<br/>[FR] ADMINISTRATION D'INHIBITEURS CALCIQUE TRPC6 À L'AIDE DE BALLONNETS, D'ENDOPROTHÈSES OU D'AUTRES DISPOSITIFS MÉDICAUX
  申请人：KLINIKUM RECHTS DER ISAR

  公开号：WO2021160625A1

  公开（公告）日：2021-08-19

  The present invention relates to a medical device suitable for being inserted into the lumen of an anatomic structure of a subject, said medical device comprising means for administration of TRPC6 inhibitor, wherein said means comprises the TRPC6 inhibitor. The present invention further concerns a method of manufacturing a medical device suitable for being inserted into the lumen of an anatomic structure of a subject. Also, the invention relates to a TRPC6 inhibitor for use in the treatment or prevention of a disease associated with neointimal hyperplasia associated with the migration of smooth muscular cells. The invention also relates to a method of treating or preventing a disease associated with neointimal hyperplasia, said method comprising administering a TRPC6 inhibitor to a subject in need thereof. Also envisaged is a method of inhibiting migration of smooth muscle cells. The invention additionally relates to an in vitro test kit comprising: (a) small muscle cells (SMCs); (b) a surface suitable for SMC cultivation coated with a TRPC6 inhibitor. Also concerned is a pharmaceutical composition comprising a TRPC6 inhibitor and a pharmaceutically acceptable carrier.