2-(4-{[2-(4-Methoxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-YL]oxy}phenyl)-1,3-dioxo-5-isoindolinecarboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-{[2-(4-Methoxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-YL]oxy}phenyl)-1,3-dioxo-5-isoindolinecarboxylic acid
• 英文别名: 2-[4-[2-(4-methoxyphenyl)-1,3-dioxoisoindol-5-yl]oxyphenyl]-1,3-dioxoisoindole-5-carboxylic acid
• 化学式: C₃₀H₁₈N₂O₈
• mdl: MFCD00305983
• 分子量: 534.5
• InChiKey: XYUCMEPTUHBBTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  131
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Dual alanyl aminopeptidase and dipeptidyl peptidase iv inhibitors for functionally influencing different cells and for treating immunological inflammatory, neuronal and other diseases
  申请人：Ansorge Siegfried

  公开号：US20070078130A1

  公开（公告）日：2007-04-05

  The present invention relates to substances capable of specifically inhibiting Ala-p-nitroanilide-cleaving peptidases and Gly-Pro-p-nitroanilide-cleaving peptidases as well, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).
• US8263636B2
  申请人：——

  公开号：US8263636B2

  公开（公告）日：2012-09-11