4-amino-4,6-dideoxy-D-glucose | 60409-15-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-amino-4,6-dideoxy-D-glucose
• 英文别名: Viosamin；4-Amino-4,6-dideoxy-D-glucopyranose；(3R,4S,5S,6R)-5-amino-6-methyloxane-2,3,4-triol
• CAS: 60409-15-6
• 化学式: C₆H₁₃NO₄
• 分子量: 163.174
• InChiKey: RJKBJEZZABBYBA-GASJEMHNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  95.9
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 4-acetamido-4,6-dideoxy-α-D-glucopyranoside 在 盐酸 作用下， 生成 4-amino-4,6-dideoxy-D-glucose
  参考文献：
  名称：

  4-氨基-4,6-二脱氧糖的合成与化学。二。葡萄糖。

  摘要：

  DOI：

  10.1021/jo01347a020

文献信息

• Somatic antigens of Shigella: Structure of the O-specific polysaccharide chain of the Shigella dysenteriae type 7 lipopolysaccharide
  作者：Yuriy A. Knirel、Vladimir V. Dashunin、Alexander S. Shashkov、Nikolay K. Kochetkov、Boris A. Dmitriev、Irina L. Hofman

  DOI：10.1016/0008-6215(88)84109-0

  日期：1988.8

  the Shigella dysenteriae type 7 O-specific polysaccharide, in addition to the previously reported 2-acetamido-2-deoxy-D-glucose and 2-acetamido-2-deoxy-D-galacturonic acid. On the basis of selective cleavage with anhydrous hydrogen fluoride and analysis by 1H- and 13C-n.m.r. spectroscopy and f.a.b.-mass spectrometry, it was concluded that the tetrasaccharide repeating-unit of the polysaccharide has

  除先前报道的2-acetamido-2-deoxy-D外，还鉴定了4-（N-乙酰基甘氨酰）氨基-4,6-dideoxy-D-葡萄糖为痢疾志贺氏菌7型O特异性多糖的组成部分。 -葡萄糖和2-乙酰氨基-2-脱氧-D-半乳糖醛酸。根据无水氟化氢的选择性裂解，并通过1H和13C-nmr光谱法和fab-mass光谱法进行分析，得出的结论是，多糖的四糖重复单元具有以下结构： D-GalNAcAN是2-乙酰氨基-2-脱氧-D-半乳糖醛酰胺，D-Qui4N是4-氨基-4,6-二脱氧-D-葡萄糖。
• Isolation of the biosynthesis genes for pseudo-oligosaccharides from Streptomyces glaucescens GLA.O, and their use
  申请人：——

  公开号：US20020192793A1

  公开（公告）日：2002-12-19

  The invention relates to a recombinant DNA molecule which comprises genes for biosynthesizing acarbose and homologous pseudo-oligosaccharides; to oligonucleotide primers for the PCR amplification of the molecule; to proteins which can be obtained by expressing the genes located on a molecule; to vectors and host cells which comprise the above-mentioned DNA molecule; to proteins which are encoded by the DNA molecule; to proteins which are expressed by means of said vectors in said host cells; to processes for preparing acarbose by introducing the characterized genes into appropriate host organisms and/or eliminating these genes from the host organisms; to processes for completing the gene cluster of genes for biosynthesizing acarbose, to processes for isolating analogous gene clusters in organisms other than Streptomyces glaucescens GLA.O, to processes for mutating promoters of endogenous acarbose biosynthesis genes for the purpose of increasing the yield of acarbose, to the use of Streptomyces glaucescens GLA.O for preparing acarbose and for preparing mutants of Streptomyces glaucescens GLA.O which are optimized with regard to the acarbose yield.

  本发明涉及一种重组DNA分子，它包括用于生物合成阿卡波糖和同源假寡糖的基因；涉及用于PCR扩增该分子的寡核苷酸引物；涉及通过表达位于分子上的基因可以获得的蛋白质；涉及包含上述DNA分子的载体和宿主细胞；涉及由DNA分子编码的蛋白质；通过上述载体在上述宿主细胞中表达的蛋白质；通过将所表征的基因导入适当的宿主生物体和/或从宿主生物体中消除这些基因来制备阿卡波糖的工艺；完成生物合成阿卡波糖的基因簇的工艺，在生物体中分离出类似基因簇的工艺，而不是 玻璃链霉菌 GLA.O，为提高阿卡波糖产量而突变内源阿卡波糖生物合成基因启动子的工艺，利用 玻璃链霉菌 GLA.O制备阿卡波糖，以及制备褐煤链霉菌的突变体 突变体 GLA.O 的突变体，这些突变体在阿卡波糖产量方面进行了优化。
• ACTIVE-SITE TITRATION OF GLYCOSYL HYDROLASES
  申请人：Novozymes A/S

  公开号：EP1658378A2

  公开（公告）日：2006-05-24
• Active-site titration of glycosyl hydrolases
  申请人：Christensen Hylling Lars Lehmann

  公开号：US20060205028A1

  公开（公告）日：2006-09-14

  The invention provides a method of screening for a property of a glycosyl hydrolase wherein the property is dependent on the concentration of the glycosyl hydrolase. The method comprises a step for determining the concentration of the glycosyl hydrolase by active site titration.
• US6306627B1
  申请人：——

  公开号：US6306627B1

  公开（公告）日：2001-10-23