2'-(L-Norvalyl)amino-2'-Deoxyadenosine | 591766-30-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2'-(L-Norvalyl)amino-2'-Deoxyadenosine
• 英文别名: (2S)-2-amino-N-[(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]pentanamide
• CAS: 591766-30-2
• 化学式: C₁₅H₂₃N₇O₄
• 分子量: 365.39
• InChiKey: NWKNSTYARDJRIZ-IEUWZBGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  174
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Orthogonal translation components for the in vivo incorporation of unnatural amino acids
  申请人：The Scripps Research Institute

  公开号：EP2383340A2

  公开（公告）日：2011-11-02

  The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E.coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.

  本发明涉及正交对 tRNA 和氨基酰-tRNA 合成酶，它们可以将非天然氨基酸掺入到在真细菌宿主细胞（如大肠杆菌）或真核细胞宿主（如酵母细胞）中生产的蛋白质中。本发明提供了例如但不限于新型正交合成酶、鉴定和制造新型合成酶的方法、生产含有非天然氨基酸的蛋白质的方法以及翻译系统。
• ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：EP1807515A2

  公开（公告）日：2007-07-18
• EP1807515A4
  申请人：——

  公开号：EP1807515A4

  公开（公告）日：2008-06-18
• Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids
  申请人：Schultz Peter G.

  公开号：US20080233611A1

  公开（公告）日：2008-09-25

  The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli , or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
• US8216804B2
  申请人：——

  公开号：US8216804B2

  公开（公告）日：2012-07-10