2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-4-formyl-4-hydroxy-3-[(2S,3S,4S,5R,6S)-4-hydroxy-6-(hydroxymethyl)-3-(methylamino)-5-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine | 128-45-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-4-formyl-4-hydroxy-3-[(2S,3S,4S,5R,6S)-4-hydroxy-6-(hydroxymethyl)-3-(methylamino)-5-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine
• CAS: 128-45-0
• 化学式: C₂₇H₄₉N₇O₁₇
• 分子量: 743.7
• InChiKey: HQXKELRFXWJXNP-FJYWXVICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -10.1
• 重原子数：
  51
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  416
• 氢给体数：
  15
• 氢受体数：
  20

文献信息

• [EN] ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE<br/>[FR] CONJUGUÉS ANIONIQUES D'UN MÉTABOLITE BACTÉRIEN GLYCOSYLÉ
  申请人：GLYCAN BIOSCIENCES PTY LTD

  公开号：WO2010037179A1

  公开（公告）日：2010-04-08

  The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.

  该发明涉及与糖基化细菌代谢产物的阴离子结合物，可用于模拟被称为糖胺聚糖（GAGs）的阴离子生物活性分子的结构和/或活性。该发明还涉及制备这些结合物的过程。这些结合物在预防和/或治疗疾病条件方面具有用处，特别是慢性疾病条件，如炎症（包括过敏）疾病、转移性癌症和感染病原体（包括细菌、病毒或寄生虫）的情况。
• [EN] METHODS FOR TREATING LEISHMANIASIS<br/>[FR] MÉTHODES DE TRAITEMENT DE LA LEISHMANIOSE
  申请人：UNIV HOWARD

  公开号：WO2013074930A1

  公开（公告）日：2013-05-23

  Methods are provided to inhibit proliferation of Leishmania parasites, and in particular Leishmania donovani with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can be used to provide prophylaxis or treatment to a patient in need of treatment against leishmaniasis disease.

  提供了一种方法来抑制利什曼原虫（Leishmania）的增殖，特别是对利什曼东非原虫（Leishmania donovani）使用带有亚胺取代的1,4-萘醌类化合物，包括新颖的化合物。给予亚胺取代的1,4-萘醌类化合物可以用于为需要治疗利什曼病的患者提供预防或治疗。
• Aminoglycoside-polyamine displacers and methods of use in displacement chromatography
  申请人：Rege Kaushal

  公开号：US20070049741A1

  公开（公告）日：2007-03-01

  Aminoglycoside-polyamines are disclosed along with methods of use thereof in displacement chromatography and as DNA-binding ligands. The aminoglycoside-polyamines are derivatives of carbohydrates, such as sugars, amino sugars, deoxysugars, glycosides, nucleosides and their substituted counterparts. The subject polyamines possess a group in place of at least one hydrogen atom of at least one hydroxyl group of the carbohydrate compound. In these compounds R 1 is an alkyl group or an azaalkyl group, and R 2 is a primary or secondary amino group.

  本文披露了氨基糖苷-多胺以及它们在置换色谱和作为DNA结合配体中的使用方法。氨基糖苷-多胺是碳水化合物的衍生物，例如糖，氨基糖，去氧糖，糖苷，核苷和它们的取代物。这些多胺具有取代至少一种碳水化合物化合物的至少一个羟基的氨基团。在这些化合物中，R1是烷基或氮杂基，R2是一级或二级氨基。
• Pharmaceutical compounds
  申请人：Soldato Del Piero

  公开号：US20050261242A1

  公开（公告）日：2005-11-24

  Compounds or their salts having general formula: A-B—C—NO 2 wherein: A is a drug radical; B is a linker; and C is a bivalent radical.

  化合物或其盐的一般式为：A-B-C-NO2，其中：A是药物基团；B是连接剂；C是双价基团。
• METHODS FOR TREATING LEISHMANIASIS
  申请人：HOWARD UNIVERSITY

  公开号：US20140336187A1

  公开（公告）日：2014-11-13

  Methods are provided to inhibit proliferation of Leishmania parasites, and in particular Leshmania donovani with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can used to provide prophylaxis or treatment to a patient in need of treatment against leishmaniasis disease.

  提供了抑制利什曼原虫增殖的方法，特别是使用含亚胺基取代的1,4-萘醌类化合物抑制利什曼原虫的增殖，包括新型化合物。给予亚胺基取代的1,4-萘醌类化合物可以用于为需要治疗利什曼病的患者提供预防或治疗。