dimethyl 6'-azidobiphenyl-2,3'-dicarboxylate | 1396893-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl 6'-azidobiphenyl-2,3'-dicarboxylate
• 英文别名: Methyl 4-azido-3-(2-methoxycarbonylphenyl)benzoate
• CAS: 1396893-82-5
• 化学式: C₁₆H₁₃N₃O₄
• 分子量: 311.297
• InChiKey: SHDXISSFFDHASS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  67
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dimethyl 6'-azidobiphenyl-2,3'-dicarboxylate 在 N-甲基吗啉 、 4-二甲氨基吡啶 、 水 、 potassium carbonate 、 苯硫酚 、 三乙胺 、 4-(4,6-二甲氧基三嗪-2-基)-4-甲基吗啉盐酸盐 、 lithium hydroxide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 11-(2-(6-azido-6'-(methoxycarbonyl)biphenyl-3-ylcarboxamido)ethyl)-2,5,8-tris(carboxymethyl)-24,24-dimethyl-10,13,22-trioxo-23-oxa-2,5,8,11,14,21-hexaazapentacosane-1-carboxylic acid
  参考文献：
  名称：

  Long-Lived Luminogenic Probe for Detection of RNA in a Crude Solution of Living Bacterial Cells

  摘要：

  A pre-type sensitizer for a lanthanide complex on an oligonucleotide was successfully converted to a perfect final structure in a target DNA/RNA-templated reaction, without any chemical reagent or enzyme, under neutral conditions. The final form of the lanthanide oligonucleotide provided a long-lived luminescence signal, appropriate for time-gated luminescence analysis and signal amplification. Target DNA/RNA-assisted time-gated luminescence analysis is a powerful tool for elimination of autofluorescence and detection of target RNA in living bacterial cells.

  DOI：

  10.1021/ja406724k
• 作为产物：
  描述：

  methyl 4-(3,3-diethyltriaz-1-enyl)-3-iodobenzoate 在 potassium phosphate 、 三苯胂 、 叠氮基三甲基硅烷 、 palladium diacetate 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.17h， 生成 dimethyl 6'-azidobiphenyl-2,3'-dicarboxylate
  参考文献：
  名称：

  Long-Lived Luminogenic Probe for Detection of RNA in a Crude Solution of Living Bacterial Cells

  摘要：

  A pre-type sensitizer for a lanthanide complex on an oligonucleotide was successfully converted to a perfect final structure in a target DNA/RNA-templated reaction, without any chemical reagent or enzyme, under neutral conditions. The final form of the lanthanide oligonucleotide provided a long-lived luminescence signal, appropriate for time-gated luminescence analysis and signal amplification. Target DNA/RNA-assisted time-gated luminescence analysis is a powerful tool for elimination of autofluorescence and detection of target RNA in living bacterial cells.

  DOI：

  10.1021/ja406724k

文献信息

• Long-Lived Luminogenic Probe for Detection of RNA in a Crude Solution of Living Bacterial Cells
  作者：Hisao Saneyoshi、Yoshihiro Ito、Hiroshi Abe

  DOI：10.1021/ja406724k

  日期：2013.9.18

  A pre-type sensitizer for a lanthanide complex on an oligonucleotide was successfully converted to a perfect final structure in a target DNA/RNA-templated reaction, without any chemical reagent or enzyme, under neutral conditions. The final form of the lanthanide oligonucleotide provided a long-lived luminescence signal, appropriate for time-gated luminescence analysis and signal amplification. Target DNA/RNA-assisted time-gated luminescence analysis is a powerful tool for elimination of autofluorescence and detection of target RNA in living bacterial cells.