(1-butyl-4c-hydroxy-4t-phenyl-[3r]piperidyl)-phenyl ketone | 13721-16-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1-butyl-4c-hydroxy-4t-phenyl-[3r]piperidyl)-phenyl ketone
• 英文别名: (1-Butyl-4c-hydroxy-4t-phenyl-[3r]piperidyl)-phenyl-keton；[(3S,4R)-1-butyl-4-hydroxy-4-phenylpiperidin-3-yl]-phenylmethanone
• CAS: 13721-16-9
• 化学式: C₂₂H₂₇NO₂
• 分子量: 337.462
• InChiKey: ZHBVPXBHHSJIMN-IRLDBZIGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ω-n-Butylaminopropiophenone oxalate 在 sodium hydroxide 作用下， 生成 (1-butyl-4c-hydroxy-4t-phenyl-[3r]piperidyl)-phenyl ketone
  参考文献：
  名称：

  1,3,4-TRISUBSTITUTED PIPERIDINE DERIVATIVES FROM MANNICH BASES

  摘要：

  DOI：

  10.1021/jo01157a022

文献信息

• Use of Inhibitors of Scavenger Receptor Class Proteins for the Treatment of Infectious Diseases
  申请人：Hannus Michael

  公开号：US20090324580A1

  公开（公告）日：2009-12-31

  The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.
• USE OF INHIBITORS OF SCAVENGER RECEPTOR CLASS PROTEINS FOR THE TREATMENT OF INFECTIOUS DISEASES
  申请人：HANNUS MICHAEL

  公开号：US20120276121A1

  公开（公告）日：2012-11-01

  The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.