Tert-butyl 3-[2-[(2-methylpropan-2-yl)oxycarbonyl-prop-2-enylamino]ethyl]indole-1-carboxylate | 462099-95-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Tert-butyl 3-[2-[(2-methylpropan-2-yl)oxycarbonyl-prop-2-enylamino]ethyl]indole-1-carboxylate
• 英文别名: tert-butyl 3-[2-[(2-methylpropan-2-yl)oxycarbonyl-prop-2-enylamino]ethyl]indole-1-carboxylate
• CAS: 462099-95-2
• 化学式: C₂₃H₃₂N₂O₄
• 分子量: 400.518
• InChiKey: WSLILPCMRQSEFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-ethoxythiocarbonylsulfanyl-3,3-dimethoxypropionate 、 Tert-butyl 3-[2-[(2-methylpropan-2-yl)oxycarbonyl-prop-2-enylamino]ethyl]indole-1-carboxylate 在 双十二烷基过氧化物 作用下， 以 various solvent(s) 为溶剂， 以25%的产率得到5-(3,3-dimethoxy-2-methoxycarbonyl-propyl)-1,2,4,5,5a,10b-hexahydro-azepino[4,5-b]indole-3,6-dicarboxylic acid di-tert-butyl ester
  参考文献：
  名称：

  Efficient construction of polycyclic alkaloid synthetic precursors by a xanthate free radical addition and Mannich cyclisation cascade

  摘要：

  Routes to synthetic precursors of Lupin and Eburna alkaloids have been developed. featuring the rapid construction of highly functionalised intermediates by the intermolecular radical coupling of xanthates and alkenes. followed by acid-mediated condensation-cyclisation. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00835-3
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 Tert-butyl 3-[2-[(2-methylpropan-2-yl)oxycarbonyl-prop-2-enylamino]ethyl]indole-1-carboxylate
  参考文献：
  名称：

  Efficient construction of polycyclic alkaloid synthetic precursors by a xanthate free radical addition and Mannich cyclisation cascade

  摘要：

  Routes to synthetic precursors of Lupin and Eburna alkaloids have been developed. featuring the rapid construction of highly functionalised intermediates by the intermolecular radical coupling of xanthates and alkenes. followed by acid-mediated condensation-cyclisation. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00835-3

文献信息

• Efficient construction of polycyclic alkaloid synthetic precursors by a xanthate free radical addition and Mannich cyclisation cascade
  作者：Edward W. Tate、Samir Z. Zard

  DOI：10.1016/s0040-4039(02)00835-3

  日期：2002.5

  Routes to synthetic precursors of Lupin and Eburna alkaloids have been developed. featuring the rapid construction of highly functionalised intermediates by the intermolecular radical coupling of xanthates and alkenes. followed by acid-mediated condensation-cyclisation. (C) 2002 Elsevier Science Ltd. All rights reserved.