5-溴-2-(4-甲基哌啶-1-基)吡啶 | 633283-66-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 5-溴-2-(4-甲基哌啶-1-基)吡啶
• 英文名称: 1-N-(5-bromopyridin-2-yl)-4-methylpiperidine
• 英文别名: 5-bromo-2-(4-methylpiperidin-1-yl)pyridine
• CAS: 633283-66-6
• 化学式: C₁₁H₁₅BrN₂
• 分子量: 255.157
• InChiKey: FGPJEESWOCDESV-UHFFFAOYSA-N

物化性质

• 沸点：
  338.8±27.0 °C(Predicted)
• 密度：
  1.335±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

SDS

MSDS英文版

反应信息

• 作为反应物：
  描述：

  5-溴-2-(4-甲基哌啶-1-基)吡啶 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 N-溴代丁二酰亚胺(NBS) 、 potassium acetate 、 sodium carbonate 、 联硼酸频那醇酯 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 二甲基亚砜 为溶剂， 反应 0.5h， 生成 3-bromo-6-(6-(4-methylpiperidin-1-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR INHIBITING BMP
  [FR] COMPOSITIONS ET PROCÉDÉS D'INHIBITION DE LA BMP

  摘要：

  本发明提供了BMP信号通路的小分子抑制剂，以及用于抑制BMP信号通路的组合物和方法。这些化合物和组合物可用于调节细胞生长、分化、增殖和凋亡，因此可用于治疗与BMP信号通路相关的疾病或症状，包括炎症、心血管疾病、血液疾病、癌症和骨骼疾病，以及用于调节细胞分化和/或增殖。这些化合物和组合物还可用于降低ApoB-100或LDL的循环水平，并治疗或预防获得性或先天性高胆固醇血症或高脂蛋白血症；与脂质吸收或代谢缺陷相关的疾病、紊乱或综合征；或由高脂血症引起的疾病、紊乱或综合征。

  公开号：

  WO2016011019A1
• 作为产物：
  描述：

  4-甲基哌啶 、 2,5-二溴吡啶 在 tris(dibenzylideneacetone)dipalladium (0) 4,5-双二苯基膦-9,9-二甲基氧杂蒽 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以98%的产率得到5-溴-2-(4-甲基哌啶-1-基)吡啶
  参考文献：
  名称：

  Selective Amination of Polyhalopyridines Catalyzed by a Palladium−Xantphos Complex

  摘要：

  Amination of 5-bromo-2-chloropyridine (1a) catalyzed by a palladium-Xantphos complex predominately gives 5-amino-2-chloropyridine product 3a in 96% isolated yield and excellent chemoselectivity (3a/4a = 97:3). Amination of 2,5-dibromopyridine (11) under the same conditions exclusively affords 2-amino-5-bromopyridine 4a.

  DOI：

  10.1021/ol0357696

文献信息

• [EN] IMIDAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'IMIDAZOLE
  申请人：INTERVET INT BV

  公开号：WO2012164071A1

  公开（公告）日：2012-12-06

  Described herein are compounds of formula (I), The compounds of formula I act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

  本文描述了式(I)的化合物。式(I)的化合物作为DGAT1抑制剂，可用于预防、治疗或作为高脂血症、糖尿病和肥胖的治疗药物。
• Compositions and Methods for Inhibiting BMP
  申请人：LEE Arthur

  公开号：US20170197968A1

  公开（公告）日：2017-07-13

  The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING BMP<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'INHIBITION DE LA BMP
  申请人：BRIGHAM & WOMENS HOSPITAL

  公开号：WO2016011019A1

  公开（公告）日：2016-01-21

  The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

  本发明提供了BMP信号通路的小分子抑制剂，以及用于抑制BMP信号通路的组合物和方法。这些化合物和组合物可用于调节细胞生长、分化、增殖和凋亡，因此可用于治疗与BMP信号通路相关的疾病或症状，包括炎症、心血管疾病、血液疾病、癌症和骨骼疾病，以及用于调节细胞分化和/或增殖。这些化合物和组合物还可用于降低ApoB-100或LDL的循环水平，并治疗或预防获得性或先天性高胆固醇血症或高脂蛋白血症；与脂质吸收或代谢缺陷相关的疾病、紊乱或综合征；或由高脂血症引起的疾病、紊乱或综合征。
• Selective Amination of Polyhalopyridines Catalyzed by a Palladium−Xantphos Complex
  作者：Jianguo Ji、Tao Li、William H. Bunnelle

  DOI：10.1021/ol0357696

  日期：2003.11.1

  Amination of 5-bromo-2-chloropyridine (1a) catalyzed by a palladium-Xantphos complex predominately gives 5-amino-2-chloropyridine product 3a in 96% isolated yield and excellent chemoselectivity (3a/4a = 97:3). Amination of 2,5-dibromopyridine (11) under the same conditions exclusively affords 2-amino-5-bromopyridine 4a.