3-(benzylsulfanylcarbonothioylsulfanyl)propionic chloride | 497931-77-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(benzylsulfanylcarbonothioylsulfanyl)propionic chloride
• 英文别名: 3-benzylsulfanylthiocarbonylsulfanylpropionic acid chloride；3-((benzylsulfanylthiocarbonyl)sufanyl)propionic acid chloride；BSPAC；3-Chloro-3-oxopropyl phenylmethyl carbonotrithioate；3-benzylsulfanylcarbothioylsulfanylpropanoyl chloride
• CAS: 497931-77-8
• 化学式: C₁₁H₁₁ClOS₃
• 分子量: 290.859
• InChiKey: NWTXFQVYTZESOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  99.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(benzylsulfanylcarbonothioylsulfanyl)propionic chloride 、 1,3,5-三(2-羟乙基)氰尿酸 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以88.1%的产率得到
  参考文献：
  名称：

  一种具有阻燃性的链转移剂及其制备方法

  摘要：

  本发明公开一种具有阻燃性的链转移剂及其制备方法；该具有阻燃性的链转移剂由3‑苯甲巯基硫代羰基丙酸发生酰氯化反应，再与1,3,5‑三(2‑羟乙基)氰尿酸发生缩合反应得到具有阻燃性的链转移剂；本发明制备具有阻燃性的链转移剂的合成工艺操作简单，没有产生有毒副产物，合成原料价格低廉，制得的链转移剂具有良好的阻燃作用，且得到链转移剂作为润滑油添加剂具有较好的抗磨性能。

  公开号：

  CN111848529A
• 作为产物：
  描述：

  3-[[(苄硫基)硫代羰基]硫基]丙酸 在 氯化亚砜 作用下， 以 四氯化碳 为溶剂， 反应 1.0h， 生成 3-(benzylsulfanylcarbonothioylsulfanyl)propionic chloride
  参考文献：
  名称：

  通过“接枝” RAFT聚合反应合成倍半硅氧烷核壳型星形杂化聚合物

  摘要：

  摘要有机/无机杂化聚合物在纳米容器和纳米载体中的潜在用途已得到广泛研究。本文通过可逆加成-断裂链转移聚合（RAFT）合成了一种星形杂化聚合物，即多面体低聚倍半硅氧烷（POSS）接枝的聚（N，N-（二甲基氨基）乙基甲基丙烯酸酯）（POSS- g -PDMA）。 ）。还研究了POSS-g -PDMA在水溶液中的pH刺激响应特性。

  DOI：

  10.1016/j.cclet.2016.04.018

文献信息

• Cleavage of polystyrene-<i>b</i> -poly(ethylene oxide) block copolymers with a trithiocarbonate linkage in solutions
  作者：Min Cao、Jian-Qi Wang、Peng-Cheng Chen、Jun-Ting Xu、Zhi-Qiang Fan

  DOI：10.1002/pola.24169

  日期：2010.9.1

  mixture (selective solvent for the PEO block). It is found that cleavage of the block copolymers can take place in all these three solvents and the cleavage ratio ranges from 76 to 86%. The micellar morphologies in selective solvents before and after cleavage were examined. It is observed that the size of the micelles is reduced after cleavage and sometimes aggregation of the micelles occurs due to removal

  在这项工作中，在嵌段之间具有三硫代碳酸酯基团的聚苯乙烯-b-聚环氧乙烷（PS- b - PEO）嵌段共聚物是通过在三硫代碳酸酯可逆加成断裂链转移（RAFT）存在下苯乙烯聚合制备的。与PEO连接的代理。在三种不同类型的溶剂中研究了UV辐射下三硫代碳酸酯基团的分解：四氢呋喃（THF，两个嵌段的通用溶剂），环己烷/二恶烷混合物（PS嵌段的选择性溶剂）和N，N-二甲基甲酰胺（DMF）/乙醇混合物（PEO嵌段的选择性溶剂）。发现嵌段共聚物的裂解可在所有这三种溶剂中进行，并且裂解率在76％至86％的范围内。检查裂解前后选择性溶剂中的胶束形态。观察到，在裂解后，胶束的尺寸减小，并且由于胶束的电晕的去除，有时胶束的聚集发生。它表明这项工作为合成可裂解的嵌段共聚物提供了一种简便而通用的方法。©2010 Wiley Periodicals，Inc. J Polym Sci A部分：Polym Chem 48：3833-4840，2010年
• Novel polycationic micelles for drug delivery and gene transfer
  作者：Jing-Ling Zhu、Han Cheng、Yue Jin、Si-Xue Cheng、Xian-Zheng Zhang、Ren-Xi Zhuo

  DOI：10.1039/b801249k

  日期：——

  A series of amphiphilic cationic methoxy polyethylene glycol-b-polyN-[3-(dimethylamino)propyl]methacrylamide-co-[2-hydroxylethylmethacrylate-poly(ε-caprolactone)]} MPEG-b-P[NDAPM-co-(HEMA-PCL)]} polymers were synthesized by combining reversible addition–fragmentation chain transfer (RAFT) polymerization and the macromonomer method. The resulting polymers were able to self-assemble into micelles in water with a critical micellar concentration (CMC) in the range of 10–30 mg L−1 and the CMC increased with the decrease in the PCL block content. It was found that the resulting polymers were able to form electrostatic complexes with plasmid DNA. The polymer–DNA complexes did not show apparent cytotoxicity in 293T cells. Importantly, the complexes exhibited good transfection efficiency in 293T cells at certain N/P ratios, while doxorubicin-loaded polymeric micelles also displayed controlled drug release. Besides, confocal microscopy showed that the drug and gene simultaneously carried by the cationic micelles could be delivered into the same cells, suggesting great potential for achieving the synergistic effect of drug and gene therapies.

  通过将可逆加成-断裂链转移（RAFT）聚合与大分子聚合相结合，合成了一系列两亲性阳离子甲氧基聚乙二醇-b-聚N-[3-（二甲基氨基）丙基]甲基丙烯酰胺-co-[2-羟乙基甲基丙烯酸酯-聚（ε-己内酰胺）]}聚合物。通过结合可逆加成-碎片链转移（RAFT）聚合和大单体法合成了 MPEG-b-P[NDAPM-co-(HEMA-PCL)]} 聚合物。所得聚合物能够在水中自组装成胶束，临界胶束浓度（CMC）在 10-30 mg L-1 之间，且随着 PCL 嵌段含量的减少，CMC 也随之增加。研究发现，生成的聚合物能够与质粒 DNA 形成静电复合物。聚合物-DNA 复合物在 293T 细胞中没有明显的细胞毒性。重要的是，在一定的 N/P 比率下，复合物在 293T 细胞中表现出良好的转染效率，而负载多柔比星的聚合物胶束也表现出可控的药物释放。此外，共聚焦显微镜显示，阳离子胶束同时携带的药物和基因可被递送到同一个细胞中，这为实现药物和基因疗法的协同效应提供了巨大的潜力。
• Well-defined donor-acceptor rod-coil diblock copolymer based on P3HT containing C60
  申请人：Yang Changduk

  公开号：US20100137518A1

  公开（公告）日：2010-06-03

  A method for the synthesis of well-defined rod-coil block copolymers consisting of P3HT donor and C 60 acceptor chromophores (P3HT-b-P(S x A y )-C 60 ) in a molecular architecture is reported for use in bulk-heterojunction (BHJ) solar cells. In thin films of the resulting block copolymer, reproducible self-assembly into well-defined “nanofibrils” is observed. This is the first example of a block copolymer containing a C 60 derivative that shows exclusively a nanofibrilar structure. A substantial improvement in device performance is achieved when the block copolymer is used as a “surfactant” for controlling the interface morphology of the P3HT:PCBM donor-acceptor phase domains within the composite.

  报道了一种用于合成P3HT给体和C60受体色团（P3HT-b-P（SxAy）-C60）的明确定义的棒-线嵌段共聚物的方法，以用于块状异质结（BHJ）太阳能电池。在所得嵌段共聚物的薄膜中，观察到可重复的自组装成明确定义的“纳米纤维”。这是第一个包含C60衍生物的嵌段共聚物，仅显示纳米纤维结构的示例。当将嵌段共聚物用作控制复合材料中P3HT：PCBM给受体相区界面形态的“表面活性剂”时，可以实现设备性能的显著提高。
• Poly(ethylene oxide)-grafted poly(N-isopropylacrylamide) networks: Preparation, characterization and rapid deswelling and reswelling behavior of hydrogels
  作者：Yaochen Zheng、Sixun Zheng

  DOI：10.1016/j.reactfunctpolym.2011.12.006

  日期：2012.3

  Poly(ethylene oxide)-grafted poly(N-isopropylacrylamide) networks (PNIPAAm-g-PEO) were prepared via the reversible addition-fragmentation chain transfer polymerization (RAFT) of N-isopropylacrylamide with trithiocarbonate-terminated poly(ethylene oxide) and N,N'-methylenebisacrylamide as the chain transfer agent and the crosslinking agent, respectively. It was found that the PNIPAAm-g-PEO copolymer networks were microphase-separated and that PEO microdomains were dispersed in the PNIPAAm matrix. The hydrogel behavior of the PNIPAAm-g-PEO networks was investigated using swelling, deswelling and reswelling tests. The PNIPAAm-g-PEO hydrogels displayed faster responses to external temperature changes than did the control PNIPAAm hydrogel. (C) 2011 Elsevier Ltd. All rights reserved.
• Synthesis of biodegradable pentaarmed star-block copolymers via an asymmetric BIS-TRIS core by combination of ROP and RAFT: From star architectures to double responsive micelles
  作者：Jianbo Li、Jie Ren、Yang Cao、Weizhong Yuan

  DOI：10.1016/j.polymer.2010.01.037

  日期：2010.3

  Biodegradable star-shaped poly(E-caprolactone) and poly(epsilon-caprolactone-b-L-lactide) (5sPCL-b-PLLA) with five arms were synthesized by ring-opening polymerization (ROP) from an asymmetric BIS-TRIS core via "core-first" strategy. Subsequently, a series of amphiphilic and double responsive star-block copolymers were synthesized by Z-RAFT star polymerization of N,N-dimethylamino-2-ethyl methacrylate (DMAEMA) from the star-shaped macro-RAFT agent, which was prepared by attaching 3-benzyl-sulfanylthiocarbonylthiocarbonylsufanylpropionic acid (BSPA) to 5sPCL-b-PLLA using a simple two-step reaction sequence GPC and H-1 NMR data demonstrated the polymerization courses are under control The molecular weight of 5sPCL-b-PLLA-b-DMAEMA increased with the monomer conversion, and the molecular weight distribution was in the range of 119-1.37. The spherical micelles with degradable core and pH/thermo-double sensitive shell had been prepared from the aqueous medium of the amphiphilic star-shaped copolymers by dialysis method Both pH and thermal-responsive behaviours of copolymer micelles obtained in this study were investigated. The micelle size and morphology were measured by DLS, AFM and TEM (C) 2010 Elsevier Ltd All rights reserved