9-Bicyclo[6.1.0]non-2-ynylmethanol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9-Bicyclo[6.1.0]non-2-ynylmethanol
• 英文别名: 9-bicyclo[6.1.0]non-2-ynylmethanol
• 化学式: C₁₀H₁₄O
• 分子量: 150.22
• InChiKey: HVKOQQBEIHHZLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• UNNATURAL AMINO ACIDS COMPRISING A CYCLOOCTYNYL OR TRANS-CYCLOOCTENYL ANALOG GROUP AND USES THEREOF
  申请人：EMBL

  公开号：US20140073764A1

  公开（公告）日：2014-03-13

  The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans-cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5-tetrazine group.

  本发明涉及含有环辛炔基或反式环辛烯基类似物基团的非天然氨基酸，其具有化学式（I）或其酸或碱加合物。该发明还涉及所述非天然氨基酸的使用，用于制备包含一个或多个环辛炔基或反式环辛烯基类似物基团的多肽的工具和过程。这些多肽可以通过体外或体内反应与含有偶氮酰基、腈氧化物、亚硝基、偶氮甲酰基或1,2,4,5-四唑基团的化合物进行共价修饰。
• METHODS OF INCORPORATING AN AMINO ACID COMPRISING A BCN GROUP INTO A POLYPEPTIDE USING AN ORTHOGONAL CODON ENCODING IT AND AN ORTHORGONAL PYLRS SYNTHASE
  申请人：MEDICAL RESEARCH COUNCIL

  公开号：US20150148525A1

  公开（公告）日：2015-05-28

  The invention relates to a polypeptide comprising an amino acid having a bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) group, particularly when said BCN group is present as: a residue of a lysine amino acid. The invention also relates to a method of producing a polypeptide comprising a BCN group, said method comprising genetically incorporating an amino acid comprising a BCN group into a polypeptide. The invention also relates to an amino acid comprising bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN), particularly and amino acid which is bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) lysine. In addition the invention relates to a PylRS tRNA synthetase comprising the mutations Y271M, L274G and C313A.

  该发明涉及一种多肽，其中包含一种具有双环[6.1.0]非-4-炔-9-基甲醇（BCN）基团的氨基酸，特别是当该BCN基团存在为：赖氨酸氨基酸的残基。该发明还涉及一种生产包含BCN基团的多肽的方法，该方法包括将含有BCN基团的氨基酸基因地合并到多肽中。该发明还涉及一种含有双环[6.1.0]非-4-炔-9-基甲醇（BCN）的氨基酸，特别是一种双环[6.1.0]非-4-炔-9-基甲醇（BCN）赖氨酸。此外，该发明涉及一种含有突变Y271M、L274G和C313A的PylRS tRNA合成酶。
• UNNATURAL AMINO ACIDS COMPRISING A NORBORNENYL GROUP AND USES THEREOF
  申请人：EMBL

  公开号：EP3279211A1

  公开（公告）日：2018-02-07

  The present invention relates to unnatural amino acids comprising a norbornenyl group and having formula or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids and processes for preparation of polypeptides that comprise one or more than one norbornenyl group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising a 1,2,4,5-tetrazine group.

  本发明涉及包含降冰片烯基并具有以下式子的非天然氨基酸 或其酸或碱加成盐。 本发明还涉及上述非天然氨基酸的用途以及制备包含一个或多个降冰片烯基的多肽的工艺。这些多肽可通过与含有 1，2，4，5-四嗪基团的化合物进行体外或体内反应进行共价修饰。
• METHODS OF INCORPORATING AN AMINO ACID COMPRISING A BCN GROUP INTO A POLYPEPTIDE USING AN ORTHOGONAL CODON ENCODING IT AND AN ORTHORGONAL PYLRS SYNTHASE.
  申请人：Medical Research Council

  公开号：EP2852664B1

  公开（公告）日：2017-09-06
• US9085514B2
  申请人：——

  公开号：US9085514B2

  公开（公告）日：2015-07-21