4-(N-pivaloylthiocarbamoyl)morpholine | 95600-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(N-pivaloylthiocarbamoyl)morpholine
• 英文别名: 2,2-dimethyl-N-(4-morpholinylcarbothioyl)propanamide；2,2-dimethyl-N-(morpholine-4-carbothioyl)propanamide
• CAS: 95600-09-2
• 化学式: C₁₀H₁₈N₂O₂S
• 分子量: 230.331
• InChiKey: RKCFKZAIWKXANH-UHFFFAOYSA-N

物化性质

• 熔点：
  136-137 °C
• 密度：
  1.153±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  73.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(N-pivaloylthiocarbamoyl)morpholine 在 溴 、 三乙胺 、 三氯氧磷 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 7.75h， 生成 4-tert-butyl-2-(4-morpholino)-5-[5-formyl-2-(4-morpholino)-4-thiazolyl]-thiazole
  参考文献：
  名称：

  Preparation and properties of 2-Dialkylamino-5-haloacetyl-thiazoles and 4-(2-Dialkylamino-5-thiazolyl)-thiazoles

  摘要：

  By the reaction of N-acylthioureas 7 with 1,3-dichloroacetone 9 2-dialkylamino-5-chloroacetyl-thiazoles 11 are avialable. These compounds react with thioureas or aryl thioamides under heterocyclisation to give bis-(2-dialkylamino-5-thiazolyl)-ketones 13, 2-aryl-4-(2-dialkylamino-5-thiazolyl)thiazoles 14, or 2-dialkylamino-4-(2-dialkylamino-5-thiazolyl)-thiazoles 15, resp., from which the last-mentioned compound exhibit a high reactivity towards several electrophilic reagents. Thus, deeply colored cyanovinyl, arylazo, and arylmethine substituted bisthiazole dyes 17, 18, and 19, resp., have been formed.

  DOI：

  10.1002/prac.19983400413
• 作为产物：
  描述：

  三甲基乙酰氯 以 丙酮 为溶剂， 反应 0.5h， 生成 4-(N-pivaloylthiocarbamoyl)morpholine
  参考文献：
  名称：

  Brindley, Jocelyn C.; Caldwell, Jennifer M.; Meakins, G. Denis, Journal of the Chemical Society. Perkin transactions I, 1987, p. 1153 - 1158

  摘要：

  DOI：

文献信息

• Funnell, Richard A.; Meakins, G. Denis; Peach, Josephine M., Journal of the Chemical Society. Perkin transactions I, 1987, p. 2311 - 2316
  作者：Funnell, Richard A.、Meakins, G. Denis、Peach, Josephine M.、Price, Susan J.

  DOI：——

  日期：——
• FUNNELL, RICHARD A.;MEAKINS, G. DENIS;PEACH, JOSEPHINE M.;PRICE, (MISS) S+, J. CHEM. SOC. PERKIN TRANS.,(1987) N 11, 2311-2315
  作者：FUNNELL, RICHARD A.、MEAKINS, G. DENIS、PEACH, JOSEPHINE M.、PRICE, (MISS) S+

  DOI：——

  日期：——
• BRINDLEY, J. C.;CALDWELL, J. M.;MEAKINS, G. D.;PLACKETT, S. J.;PRICE, S. +, J. CHEM. SOC. PERKIN TRANS.,(1987) N 5, 1153-1158
  作者：BRINDLEY, J. C.、CALDWELL, J. M.、MEAKINS, G. D.、PLACKETT, S. J.、PRICE, S. +

  DOI：——

  日期：——
• Brindley, Jocelyn C.; Caldwell, Jennifer M.; Meakins, G. Denis, Journal of the Chemical Society. Perkin transactions I, 1987, p. 1153 - 1158
  作者：Brindley, Jocelyn C.、Caldwell, Jennifer M.、Meakins, G. Denis、Plackett, Simon J.、Price, Susan J.

  DOI：——

  日期：——
• Preparation and properties of 2-Dialkylamino-5-haloacetyl-thiazoles and 4-(2-Dialkylamino-5-thiazolyl)-thiazoles
  作者：Cornelia Mokry、Horst Hartmann

  DOI：10.1002/prac.19983400413

  日期：——

  By the reaction of N-acylthioureas 7 with 1,3-dichloroacetone 9 2-dialkylamino-5-chloroacetyl-thiazoles 11 are avialable. These compounds react with thioureas or aryl thioamides under heterocyclisation to give bis-(2-dialkylamino-5-thiazolyl)-ketones 13, 2-aryl-4-(2-dialkylamino-5-thiazolyl)thiazoles 14, or 2-dialkylamino-4-(2-dialkylamino-5-thiazolyl)-thiazoles 15, resp., from which the last-mentioned compound exhibit a high reactivity towards several electrophilic reagents. Thus, deeply colored cyanovinyl, arylazo, and arylmethine substituted bisthiazole dyes 17, 18, and 19, resp., have been formed.