3,3-Dimethyl-4-(2,4,6-trichloropyrimidin-5-yl)oxybutan-2-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3-Dimethyl-4-(2,4,6-trichloropyrimidin-5-yl)oxybutan-2-ol
• 英文别名: 3,3-dimethyl-4-(2,4,6-trichloropyrimidin-5-yl)oxybutan-2-ol
• 化学式: C₁₀H₁₃Cl₃N₂O₂
• 分子量: 299.6
• InChiKey: BDWNTQWVOGEHBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  55.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• DIOXINO- AND OXAZIN-[2,3-D]PYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2890698A1

  公开（公告）日：2015-07-08
• [EN] DIOXINO- AND OXAZIN-[2,3-D]PYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS DIOXINO- ET OXAZINE-[2,3-D]PYRIMIDINE, INHIBITEURS DE PI3K, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014033196A1

  公开（公告）日：2014-03-06

  Dioxino- and oxazin-[2,3-d]pyrimidine PI3K inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions.