[4-[2-[3-Cyano-5-(2-morpholin-4-ylethoxy)anilino]pyrimidin-4-yl]oxynaphthalen-1-yl]carbamic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [4-[2-[3-Cyano-5-(2-morpholin-4-ylethoxy)anilino]pyrimidin-4-yl]oxynaphthalen-1-yl]carbamic acid
• 英文别名: [4-[2-[3-cyano-5-(2-morpholin-4-ylethoxy)anilino]pyrimidin-4-yl]oxynaphthalen-1-yl]carbamic acid
• 化学式: C₂₈H₂₆N₆O₅
• 分子量: 526.5
• InChiKey: CRDVAPGNQBPAHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• KINASE INHIBITORS
  申请人：Respivert Limited

  公开号：US20160340375A1

  公开（公告）日：2016-11-24

  There are provided compounds of formula I. wherein R 1 to R 5 , X 1 , X 2 , Ar, L, A, A 1 , E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了具有式I的化合物，其中R1至R5，X1，X2，Ar，L，A，A1，E和G的含义如描述中所给，这些化合物具有抗炎活性（例如通过抑制p38丝裂原活化蛋白激酶家族的一个或多个成员；Syk激酶；以及酪氨酸激酶Src家族的成员之一）并且在治疗中有用，包括在药物组合中，特别是用于治疗包括肺部、眼睛和肠道炎症疾病在内的炎症性疾病。
• US9796742B2
  申请人：——

  公开号：US9796742B2

  公开（公告）日：2017-10-24
• [EN] KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASES
  申请人：RESPIVERT LTD

  公开号：WO2014033446A1

  公开（公告）日：2014-03-06

  There are provided compounds of formula (I), (Formula (I)) wherein R1 to R5, X1, X2, Ar, L, A, A1, E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.