Azane;butane;1,1-diethoxyethane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Azane;butane;1,1-diethoxyethane
• 英文别名: azane;butane;1,1-diethoxyethane
• 化学式: C10H27NO2
• 分子量: 193.33
• InChiKey: YYTJUWNIFVTMCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.37
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  19.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• CYCLOPROPANECARBOXYLATE ESTERS OF PURINE ANALOGUES
  申请人：Annji Pharmaceutical Co., Ltd.

  公开号：EP2838538A1

  公开（公告）日：2015-02-25
• [EN] CYCLOPROPANECARBOXYLATE ESTERS OF PURINE ANALOGUES<br/>[FR] ESTERS DE CYCLOPROPANECARBOXYLATE D'ANALOGUES DE PURINES
  申请人：ANNJI PHARM CO LTD

  公开号：WO2013158367A1

  公开（公告）日：2013-10-24

  Cydopropanecarboxylate esters of purine analogues, method of making and using the same for treating herpes virus infections and tumors are disclosed. In an embodiment of the invention, the compound of the invention may be used for treating cancer A cancer patient may be first administered a vector, such as an adenovector, comprising a DNA insert encoding HSV thymidme kinase, said vector expressing HSV thymidine kinase in the tumor cells of the subject, followed by administration of the compound of the invention. In another aspect the invention relates to use of a compound or a pharmaceutically acceptable salt, a solvate or hydrate, a prodrug, or a metabolite thereof as aforementioned in the manufacture of a medicament for treating herpes virus infection. The medicament may be for treating herpes simplex virus infection, herpes zoster infection, or cytomegalovirus infection.