[(2R,3R,4R,5R)-4-fluoro-2,3,5,7-tetrahydroxy-6-oxoheptyl] dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3R,4R,5R)-4-fluoro-2,3,5,7-tetrahydroxy-6-oxoheptyl] dihydrogen phosphate
• 化学式: C₇H₁₄FO₉P
• 分子量: 292.15
• InChiKey: OTFWTFZQGOCTJK-XZBKPIIZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  165
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• [EN] A POSITRON EMISSION TOMOGRAPHY PROBE TO MONITOR SELECTED SUGAR METABOLISM IN VIVO<br/>[FR] SONDE DE TOMOGRAPHIE PAR ÉMISSION DE POSITRONS DESTINÉE À SURVEILLER LE MÉTABOLISME D'UN SUCRE SÉLECTIONNÉ IN VIVO
  申请人：UNIV CALIFORNIA

  公开号：WO2013170085A1

  公开（公告）日：2013-11-14

  The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.

  本发明披露了选定的核糖异构体，这些异构体可用作PET探针（例如[18F]-2-氟-2-脱氧-阿拉伯糖）。这些PET探针可用于监测生理过程，包括核糖代谢，或者选择性地观察体内的某些组织/器官。本发明还提供了制备和使用这些探针的方法。
• POSITRON EMISSION TOMOGRAPHY PROBE TO MONITOR SELECTED SUGAR METABOLISM IN VIVO
  申请人：The Regents of the University of California

  公开号：US20150133777A1

  公开（公告）日：2015-05-14

  The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metabolism and/or to selectively observe certain tissue/organs in vivo. The invention disclosed herein further provides methods for making and using such probes.
• US9592309B2
  申请人：——

  公开号：US9592309B2

  公开（公告）日：2017-03-14