1-(3,5-Dichloro-2-hydroxyphenyl)-1-decanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3,5-Dichloro-2-hydroxyphenyl)-1-decanone
• 英文别名: 1-(3,5-dichloro-2-hydroxyphenyl)decan-1-one
• 化学式: C₁₆H₂₂Cl₂O₂
• 分子量: 317.2
• InChiKey: KTGWXAFGOCFYSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF
  申请人：Stemergie Biotechnology SA

  公开号：EP2852439A1

  公开（公告）日：2015-04-01
• US9458174B2
  申请人：——

  公开号：US9458174B2

  公开（公告）日：2016-10-04
• [EN] INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF<br/>[FR] INHIBITEURS DE L'ACTIVITÉ DU COMPLEXE (III) DE LA CHAÎNE DE TRANSPORT D'ÉLECTRONS MITOCHONDRIALE ET UTILISATION DE CEUX-CI
  申请人：STEMERGIE BIOTECHNOLOGY SA

  公开号：WO2013174947A1

  公开（公告）日：2013-11-28

  The present invention relates to inhibitors of the activity of Complex (III) of the mitochondrial electron transport chain and use thereof in treatment and/or prevention of cancers presenting tumour-initiating cells. The present invention further relates to pharmaceutical compositions containing said inhibitors alone or in combination with other pharmaceutically active agents, and their use as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit.