[4-[4-(4-Bromophenyl)-2,4-dioxobutyl]phenyl]carbamic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [4-[4-(4-Bromophenyl)-2,4-dioxobutyl]phenyl]carbamic acid
• 英文别名: [4-[4-(4-bromophenyl)-2,4-dioxobutyl]phenyl]carbamic acid
• 化学式: C₁₇H₁₄BrNO₄
• 分子量: 376.2
• InChiKey: FEPJSCUBZBYDBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3<br/>[FR] DÉRIVÉS DE PYRAZOLE EN TANT QU'INHIBITEURS DE STAT3
  申请人：MAYO FOUNDATION

  公开号：WO2013187965A1

  公开（公告）日：2013-12-19

  Compositions that modulate the activity of signal transducer and activator of transcription-3 (STAT3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as substituted pyrazoles and are useful in treatment of diseases related to the activity of STAT3 including, for example, cancer and other diseases.

  提供了调节信号转导子和激活子STAT3活性的组合物，以及它们的使用方法，如治疗和成像。这些组合物包含小分子，如取代吡唑，并且在治疗与STAT3活性相关的疾病方面非常有用，例如癌症和其他疾病。
• PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3
  申请人：Mayo Foundation for Medical Education and Research

  公开号：US20150166484A1

  公开（公告）日：2015-06-18

  Compositions that modulate the activity of signal transducer and activator of transcription-3 (STAT3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as substituted pyrazoles and are useful in treatment of diseases related to the activity of STAT3 including, for example, cancer and other diseases.

  本文提供了调节信号转导和激活转录因子-3（STAT3）活性的组合物以及它们的使用方法，例如治疗和成像。这些组合物包含小分子，如取代的吡唑，并且在治疗与STAT3活性相关的疾病，例如癌症和其他疾病方面非常有用。
• Pyrazole derivatives as inhibitors of STAT3
  申请人：Mayo Foundation for Medical Education and Research

  公开号：US10138208B2

  公开（公告）日：2018-11-27

  Compositions that modulate the activity of signal transducer and activator of transcription-3 (STAT3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as substituted pyrazoles and are useful in treatment of diseases related to the activity of STAT3 including, for example, cancer and other diseases.

  提供了调节信号转导子和转录激活子-3（STAT3）活性的组合物及其使用方法，如治疗和成像。组合物含有取代吡唑等小分子，可用于治疗与 STAT3 活性有关的疾病，例如癌症和其他疾病。
• US9732038B2
  申请人：——

  公开号：US9732038B2

  公开（公告）日：2017-08-15