4-amino-1H-imidazole-5-carboxamide;[(2R,3S,4R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-amino-1H-imidazole-5-carboxamide;[(2R,3S,4R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C9H17N4O9P
• 分子量: 356.23
• InChiKey: XFVNDBRIVXLRTR-QHEAFLAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.37
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  235
• 氢给体数：
  8
• 氢受体数：
  11

文献信息

• [EN] PHARMACEUTICAL COMPOSITIONS COMPRISING A HEAT SHOCK PROTEIN INHIBITOR AND A|PURINE DE NOVO SYNTHESIS INHIBITOR FOR TREATING RHEUMATOID ARTHRITIS OR CANCER<br/>[FR] COMPOSITIONS PHARMACEUTIQUES COMPRENANT UN INHIBITEUR DE PROTÉINE DE CHOC THERMIQUE ET UN INHIBITEUR DE SYNTHÈSE DE NOVO D'UNE PURINE POUR LE TRAITEMENT DE LA POLYARTHRITE RHUMATOÏDE OU DU CANCER
  申请人：CORNING INC

  公开号：WO2014018862A1

  公开（公告）日：2014-01-30

  A pharmaceutical composition including an effective amount of the combination of: an heat shock protein (HSP) inhibitor, and a purine de novo biosynthesis inhibitor, or a pharmaceutically acceptable salt thereof. Also disclosed is a method of treating rheumatoid arthritis or cancer including administering an effective amount of the above mentioned pharmaceutical composition to a patient in need of such treatment, as defined herein.