(2R,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal;propane-1,2,3-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal;propane-1,2,3-triol
• 化学式: C9H21NO8
• 分子量: 271.26
• InChiKey: CZUQVLFHROFVGT-BTVCFUMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.08
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  185
• 氢给体数：
  8
• 氢受体数：
  9

文献信息

• [EN] PRION-BASED MANIPULATION OF YEAST FERMENTATION AND GROWTH<br/>[FR] MANIPULATION À BASE DE PRIONS DE LA FERMENTATION ET LA CROISSANCE DE LEVURES
  申请人：WHITEHEAD BIOMEDICAL INST

  公开号：WO2014022692A1

  公开（公告）日：2014-02-06

  In some aspects, the invention provides methods of modulating yeast fermentation or growth by modulating the [GAR+] prion. In some embodiments, [GAR+] is induced by contacting yeast cells with a bacterium that produces a small molecule inducer of [GAR+] or by contacting yeast cells with the small molecule or conditioned medium comprising the small molecule or a fraction of such medium that comprises the small molecule. In some aspects, the invention provides methods of identifying a modulator of a prion of interest. In some embodiments a methods of identifying a modulator of a prion comprises (a) providing a bacterially conditioned medium; (b) contacting at least one fraction of the bacterially conditioned medium with a non-bacterial cell; and (c) monitoring the cell for alteration of a phenotype assocatied with a prion of interest. In some embodiments the non-bacterial cell is a yeast cell. In some embodiments the prion is [GAR+].