4-tert-butyl-N-(2-methyl-6-oxo-1H-pyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-3-yl]oxybenzamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-tert-butyl-N-(2-methyl-6-oxo-1H-pyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-3-yl]oxybenzamide
• 化学式: C₂₃H₂₂F₃N₃O₃
• 分子量: 445.4
• InChiKey: LNLCYEJQCLJQSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  80.3
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] SOLID FORMS OF (4-ISOPROPOXY-3-METHOXYPHENYL)(2'-METHYL-6'-(TRIFLUOROMETHYL)-3',4'-DIHYDRO-2'H-SPIRO[PIPERIDINE-4,1'-PYRROLO[1,2-A]PYRAZINE]-1-YL)METHANONE<br/>[FR] FORMES SOLIDES DE (4-ISOPROPOXY-3-MÉTHOXYPHÉNYL)(2'-MÉTHYL-6'-(TRIFLUOROMÉTHYL)-3',4'-DIHYDRO-2'H-SPIRO[PIPÉRIDINE-4,1'-PYRROLO[1,2-A]PYRAZINE]-1-YL)MÉTHANONE
  申请人：VERTEX PHARMA

  公开号：WO2014022639A1

  公开（公告）日：2014-02-06

  The invention relates to solid state forms, for example, crystalline forms, of (4-isopropoxy-3-methoxyphenyl)(2'-methyl-6'-(trifluoromethyl)-3,,4'- dihydro-2'H-spiro[piperidine-4, 1 '-pyrrolo[ 1,2-a]pyrazine]- 1 -yl)methanone (Compound 1) or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods therewith. The present invention also relates to a method of preparing Compound 1 in various solid forms. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders such as pain.

  该发明涉及固态形式，例如，(4-异丙氧基-3-甲氧基苯基)(2'-甲基-6'-(三氟甲基)-3,4'-二氢-2'H-螺[哌啶-4,1'-吡咯[1,2-a]吡嗪]-1-基)甲酮（化合物1）或其药学上可接受的盐的晶体形式，其制备方法以及药物组合物。本发明还涉及制备化合物1的各种固态形式的方法。该发明还提供了包括本发明化合物的药学上可接受的组合物以及使用这些组合物治疗各种疾病（如疼痛）的方法。
• PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2953931A1

  公开（公告）日：2015-12-16
• [EN] PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS<br/>[FR] PYRIDONE AMIDES COMME MODULATEURS DES CANAUX SODIQUES
  申请人：VERTEX PARMACEUTICALS INC

  公开号：WO2014120808A1

  公开（公告）日：2014-08-07

  The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.