3-[(3,4-dihydroxybenzoyl)amino]-2-methyl-N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]benzamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[(3,4-dihydroxybenzoyl)amino]-2-methyl-N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]benzamide
• 化学式: C₂₁H₂₄N₂O₉
• 分子量: 448.4
• InChiKey: OGDXNPKEBVGDTB-VNTIUTJASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  189
• 氢给体数：
  8
• 氢受体数：
  9

文献信息

• CONJUGATED ANTI-MICROBIAL COMPOUNDS AND CONJUGATED ANTI-CANCER COMPOUNDS AND USES THEREOF
  申请人：PONO CORPORATION

  公开号：US20150150995A1

  公开（公告）日：2015-06-04

  Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.

  本文公开了合成共轭抗微生物化合物和共轭抗癌化合物的方法。其中几种实施例与上述化合物在治疗感染方面的应用有关，特别是那些由耐药细菌引起的感染。一些实施例涉及基于肿瘤细胞代谢特征的癌症治疗。
• [EN] CONJUGATED ANTI-MICROBIAL COMPOUNDS AND CONJUGATED ANTI-CANCER COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ANTIMICROBIENS CONJUGUÉS ET COMPOSÉS ANTICANCÉREUX CONJUGUÉS ET LEURS UTILISATIONS
  申请人：PONO CORP

  公开号：WO2014026143A1

  公开（公告）日：2014-02-13

  Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.