2-amino-3,7-dihydropurine-6-thione;(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-amino-3,7-dihydropurine-6-thione;(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 化学式: C15H17FN10O4S
• 分子量: 452.4
• InChiKey: LJWHNVDRQWVIJZ-ITHLILATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.24
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  251
• 氢给体数：
  7
• 氢受体数：
  11

文献信息

• VECTORS FOR DELIVERY OF AGENTS ACROSS BIOLOGICAL MEMBRANES
  申请人：The Regents of the University of California

  公开号：US20160030590A1

  公开（公告）日：2016-02-04

  The disclosure provides for peptide-based bolaamphiphile vectors that are capable of encapsulating a variety of agents, including peptides, proteins, nucleic acids, and drugs. The disclosure further provides for delivering these agents across biological membranes using the peptide-based bolaamphiphile vectors.

  该披露提供了基于肽的双极胶束载体，能够封装各种药剂，包括肽、蛋白质、核酸和药物。此外，该披露还提供了使用基于肽的双极胶束载体将这些药剂跨越生物膜输送的方法。
• COMPOSITIONS COMPRISING CHITOSAN-DRUG CONJUGATES AND METHODS OF MAKING AND USING THE SAME
  申请人：AHMAD Farhan J.

  公开号：US20150202321A1

  公开（公告）日：2015-07-23

  The present disclosure relates to nanosized chitosan-statin conjugates, nanosized chitosan-chemotherapeutic agent conjugates, compositions comprising such nanosized chitosan-drug conjugates, and methods of making and using the same. The compositions result in unexpected and dramatic improved bioavailability of the component statin or chemotherapeutic agent.
• US9867845B2
  申请人：——

  公开号：US9867845B2

  公开（公告）日：2018-01-16
• [EN] COMPOSITIONS COMPRISING CHITOSAN-DRUG CONJUGATES AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSITIONS COMPRENANT DES CONJUGUÉS CHITOSANE-MÉDICAMENT ET PROCÉDÉS PERMETTANT DE PRODUIRE ET D'UTILISER CELLES-CI
  申请人：NEWGEN BIOPHARMA CORP

  公开号：WO2014028587A1

  公开（公告）日：2014-02-20

  The present disclosure relates to nanosized chitosan-statin conjugates, nanosized chitosan-chemotherapeutic agent conjugates, compositions comprising such nanosized chitosan-drug conjugates, and methods of making and using the same. The compositions result in unexpected and dramatic improved bioavailability of the component statin or chemotherapeutic agent.