4-[4-[[[5-chloro-4-methyl-2-(pyrrolidin-2-ylmethoxy)phenyl]carbamoylamino]methyl]phenoxy]-N-methylpyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[4-[[[5-chloro-4-methyl-2-(pyrrolidin-2-ylmethoxy)phenyl]carbamoylamino]methyl]phenoxy]-N-methylpyridine-2-carboxamide
• 化学式: C₂₇H₃₀ClN₅O₄
• 分子量: 524.0
• InChiKey: MOKWQJNHEZPVCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
  申请人：Merck Patent GmbH

  公开号：US20150225369A1

  公开（公告）日：2015-08-13

  The present invention relates to compounds of the formula I and in particular medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which DDR2 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.

  本发明涉及公式I的化合物，特别是包含至少一种公式I化合物的药物，用于治疗和/或预防生理和/或病理状态，其中触发DDR2参与，特别是用于治疗和/或预防骨关节炎、肝硬化、创伤性软骨损伤、疼痛、触痛或过敏性疼痛。
• [EN] DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS<br/>[FR] INHIBITEURS DE DDR2 POUR LE TRAITEMENT DE L'ARTHROSE
  申请人：MERCK PATENT GMBH

  公开号：WO2014032755A2

  公开（公告）日：2014-03-06

  The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which DDR2 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.