4-[2-ethyl-4-[[(4-methylpyridin-2-yl)carbamoylamino]methyl]phenoxy]-N-methylpyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[2-ethyl-4-[[(4-methylpyridin-2-yl)carbamoylamino]methyl]phenoxy]-N-methylpyridine-2-carboxamide
• 化学式: C₂₃H₂₅N₅O₃
• 分子量: 419.5
• InChiKey: JDRJFHFNFIUWIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
  申请人：Merck Patent GmbH

  公开号：EP2890380A2

  公开（公告）日：2015-07-08
• [EN] DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS<br/>[FR] INHIBITEURS DE DDR2 POUR LE TRAITEMENT DE L'ARTHROSE
  申请人：MERCK PATENT GMBH

  公开号：WO2014032755A2

  公开（公告）日：2014-03-06

  The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which DDR2 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.