Fluorodeoxysorbitol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Fluorodeoxysorbitol
• 英文别名: (2R,3R,4S,5R)-6-fluorohexane-1,2,3,4,5-pentol
• 化学式: C₆H₁₃FO₅
• 分子量: 184.16
• InChiKey: ASKYZMAYXZUXQF-SLPGGIOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  101
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS FOR DETECTING CCR2 RECEPTORS
  申请人：Liu Yongjian

  公开号：US20170348442A1

  公开（公告）日：2017-12-07

  Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating CCR2 associated diseases, disorders, and conditions.

  本公开涉及的各个方面包括提供成像剂组合物和方法，用于检测、监测和评估与CCR2相关的疾病、障碍和病况。
• [EN] POSITRON IMAGING TOMOGRAPHY IMAGING AGENT COMPOSITION AND METHOD FOR DETECTION OF BACTERIAL INFECTION<br/>[FR] COMPOSITION D'AGENT D'IMAGERIE POUR TOMOGRAPHIE PAR ÉMISSION DE POSITRONS ET PROCÉDÉ DE DÉTECTION D'INFECTION BACTÉRIENNE
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2021226076A1

  公开（公告）日：2021-11-11

  This invention provides a composition comprising the compound having the structure: ethyl 2-[19F]F-4-nitrobenzoate, and at least one acceptable carrier. This invention also provides a method of detecting the presence of or location of bacteria cells in a subject which comprises determining if an amount of the compound or determining where an amount of the compound having the structure: is present in the subject at a period of time after administration of the compound or salt thereof to the subject, thereby detecting the presence of or location of the bacteria cells based on the amount of the compound determined to be present in the subject or detecting the location of the bacteria cells based on the location of the compound determined to be present in the subject.

  本发明提供了一种组合物，包括具有结构的化合物：乙基2-[19F]F-4-硝基苯酸酯，以及至少一种可接受载体。本发明还提供了一种检测主体中细菌细胞存在或位置的方法，其中包括确定化合物的数量，或确定化合物在给主体或其盐的化合物在给主体后一段时间内是否存在于主体中，从而根据确定存在于主体中的化合物的数量检测细菌细胞的存在或位置，或根据确定存在于主体中的化合物的位置检测细菌细胞的位置。
• [EN] ONE-STEP KIT-BASED SYNTHESIS OF 2-DEOXY-2-[18F]FLUORO-D-SORBITOL<br/>[FR] SYNTHÈSE DE 2-DÉSOXY-2-[18F]FLUORO-D-SORBITOL BASÉE SUR UN KIT EN UNE ÉTAPE
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2022047202A1

  公开（公告）日：2022-03-03

  A self-contained kit and method for the on-demand synthesis of 2-deoxy-2-[18F]fluoro-D-sorbitol (18F-FDS) from commercially available 2-deoxy-2-[18F]fluoroglucose (18F-FDG) is disclosed.

  本发明揭示了一种自包含套件和方法，用于从商业上可获得的2-脱氧-2-[18F]氟葡萄糖（18F-FDG）中按需合成2-脱氧-2-[18F]氟-D-山梨醇（18F-FDS）。
• Bacteria-specific labeled substrtates as imaging biomarkers to diagnose, locate, and monitor infections
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US11268958B2

  公开（公告）日：2022-03-08

  The methods of the present invention exploit unique biochemical pathways present within infectious organisms to develop small molecule metabolic tracers. Labeled substrates created using these inventive methods were created. The labeled substrates can be used to determine whether a subject is infected with an infectious organism by imaging means, and with use of two or more such labeled substrates, methods of differentiating gram negative infection from gram positive infection, and methods of localizing and quantifying infectious disease burden are provided. The methods of the present invention can assist in the clinical decision to begin empiric antibiotic therapy, determine its efficacy, as well as the choice of antibacterial agents.

  本发明的方法利用感染性生物中存在的独特生化途径，开发小分子代谢示踪剂。使用这些创新方法创建了标记底物。这些标记底物可用于通过成像手段确定受试者是否感染了感染性生物，使用两种或多种此类标记底物，提供区分革兰氏阴性感染和革兰氏阳性感染的方法，以及定位和量化感染性疾病负担的方法。本发明的方法可以帮助做出开始经验性抗生素治疗的临床决策，确定其疗效，以及选择抗菌药物。
• [EN] POSITRON IMAGING TOMOGRAPHY IMAGING AGENT COMPOSITION AND METHOD FOR BACTERIAL INFECTION<br/>[FR] COMPOSITION D'AGENT D'IMAGERIE PAR TOMOGRAPHIE PAR IMAGERIE DE POSITRONS ET MÉTHODE POUR INFECTION BACTÉRIENNE
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2018048882A9

  公开（公告）日：2019-01-10