(2S,3S,4R,5R)-2-fluorohexane-1,2,3,4,5,6-hexol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,4R,5R)-2-fluorohexane-1,2,3,4,5,6-hexol
• 化学式: C₆H₁₃FO₆
• 分子量: 200.16
• InChiKey: RQVJVLJKNMMVQA-ARQDHWQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  121
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• Bacteria-specific labeled substrtates as imaging biomarkers to diagnose, locate, and monitor infections
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US11268958B2

  公开（公告）日：2022-03-08

  The methods of the present invention exploit unique biochemical pathways present within infectious organisms to develop small molecule metabolic tracers. Labeled substrates created using these inventive methods were created. The labeled substrates can be used to determine whether a subject is infected with an infectious organism by imaging means, and with use of two or more such labeled substrates, methods of differentiating gram negative infection from gram positive infection, and methods of localizing and quantifying infectious disease burden are provided. The methods of the present invention can assist in the clinical decision to begin empiric antibiotic therapy, determine its efficacy, as well as the choice of antibacterial agents.

  本发明的方法利用感染性生物中存在的独特生化途径，开发小分子代谢示踪剂。使用这些创新方法创建了标记底物。这些标记底物可用于通过成像手段确定受试者是否感染了感染性生物，使用两种或多种此类标记底物，提供区分革兰氏阴性感染和革兰氏阳性感染的方法，以及定位和量化感染性疾病负担的方法。本发明的方法可以帮助做出开始经验性抗生素治疗的临床决策，确定其疗效，以及选择抗菌药物。
• 18F-FLUORODEOXYSORBITOL FOR USE IN IDENTIFYING AN INFECTIOUS PROKARYOTIC ENTEROBACTERIACEAE ORGANISM IN A MAMMALIAN HOST
  申请人：The Johns Hopkins University

  公开号：EP2895205B1

  公开（公告）日：2022-01-05
• BACTERIA-SPECIFIC LABELED SUBSTRATES AS IMAGING BIOMARKERS TO DIAGNOSE, LOCATE, AND MONITOR INFECTIONS
  申请人：The Johns Hopkins University

  公开号：EP2895205A1

  公开（公告）日：2015-07-22
• TUMOR AND IMMUNE CELL IMAGING BASED ON PD-L1 EXPRESSION
  申请人：The Johns Hopkins University

  公开号：EP3558395A1

  公开（公告）日：2019-10-30
• BACTERIA-SPECIFIC LABELED SUBSTRTATES AS IMAGING BIOMARKERS TO DIAGNOSE, LOCATE, AND MONITOR INFECTIONS
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20150250906A1

  公开（公告）日：2015-09-10

  The methods of the present invention exploit unique biochemical pathways present within infectious organisms to develop small molecule metabolic tracers. Labeled substrates created using these inventive methods were created. The labeled substrates can be used to determine whether a subject is infected with an infectious organism by imaging means, and with use of two or more such labeled substrates, methods of differentiating gram negative infection from gram positive infection, and methods of localizing and quantifying infectious disease burden are provided. The methods of the present invention can assist in the clinical decision to begin empiric antibiotic therapy, determine its efficacy, as well as the choice of antibacterial agents.