5-(4-amino-2,6-dichlorophenoxy)-4-propan-2-yl-1H-pyridazin-6-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(4-amino-2,6-dichlorophenoxy)-4-propan-2-yl-1H-pyridazin-6-one
• 化学式: C₁₃H₁₃Cl₂N₃O₂
• 分子量: 314.16
• InChiKey: QMDPXQVHMJJERU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF
  申请人：Madrigal Pharmaceuticals, Inc.

  公开号：EP2895466A1

  公开（公告）日：2015-07-22
• [EN] METHOD OF SYNTHESIZING THYROID HORMONE ANALOGS AND POLYMORPHS THEREOF<br/>[FR] PROCÉDÉ DE SYNTHÈSE D'ANALOGUES DE L'HORMONE THYROÏDIENNE ET DE SES POLYMORPHES
  申请人：MADRIGAL PHARMACEUTICALS INC

  公开号：WO2014043706A1

  公开（公告）日：2014-03-20

  The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRP mutation.