Dihydrofuro[3,4-c]pyridinone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: Dihydrofuro[3,4-c]pyridinone
• 英文别名: 3a,4-dihydro-3H-furo[3,4-c]pyridin-1-one
• 化学式: C₇H₇NO₂
• 分子量: 137.14
• InChiKey: QCOQEWGTRHDSOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS
  申请人：The Research Institute at Nationwide Children's Hospital

  公开号：EP2895606A2

  公开（公告）日：2015-07-22
• US9539307B2
  申请人：——

  公开号：US9539307B2

  公开（公告）日：2017-01-10
• [EN] COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE LA SCLÉROSE LATÉRALE AMYOTROPHIQUE
  申请人：RES INST NATIONWIDE CHILDRENS HOSPITAL

  公开号：WO2014043696A2

  公开（公告）日：2014-03-20

  The invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis. In particular, the invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis by decreasing the expression of a cytoplasmic granule toxin in astrocytes of a patient, or by increasing the expression of MHC class I in motor neurons of the patient.