(3R,6S)-3,6-dimethyloxane-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (3R,6S)-3,6-dimethyloxane-2,5-dione
• 化学式: C₇H₁₀O₃
• 分子量: 142.15
• InChiKey: NXCCUNRKFIAWFF-UHNVWZDZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Amorphous poly (d,l-lactide) coating
  申请人：Abbott Cardiovascular Systems Inc.

  公开号：EP2708584A2

  公开（公告）日：2014-03-19

  Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

  本发明提供了由一种材料形成或涂覆有一种材料的可植入装置，该材料包括由一种起始材料（如介-D,L-内酰胺）形成的无定形聚（D,L-内酰胺）。该植入装置可用于治疗、缓解、预防或抑制动脉粥样硬化、血栓形成、再狭窄、出血、血管剥离或穿孔、血管动脉瘤、易损斑块、慢性全闭塞、卵圆孔未闭、跛行、静脉和人工移植物吻合口增生、胆管阻塞、输尿管阻塞、肿瘤阻塞等疾病或其组合。