1-[2-(Butoxymethoxy)phenyl]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)butane-1,4-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-(Butoxymethoxy)phenyl]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)butane-1,4-dione
• 英文别名: 1-[2-(butoxymethoxy)phenyl]-4-(2,3-dihydro-1,4-benzodioxin-6-yl)butane-1,4-dione
• 化学式: C₂₃H₂₆O₆
• 分子量: 398.4
• InChiKey: SOUYWGBGRSTSLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• B- AND y -DIKETONES AND y -HYDROXYKETONES AS WNT/ B -CATENIN SIGNALING PATHWAY ACTIVATORS
  申请人：Samumed, LLC

  公开号：US20140080902A1

  公开（公告）日：2014-03-20

  The present invention discloses β-diketones, γ-diketones or γ-hydroxyketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

  本发明揭示了β-二酮、γ-二酮或γ-羟基酮或其类似物，其激活Wnt/β-连环蛋白信号传导，从而治疗或预防与信号传导相关的疾病，如骨质疏松症和骨关节病；成骨不全症、骨缺陷、骨折、牙周病、耳硬化症、伤口愈合、颅颜部缺陷、肿瘤溶解性骨病、与中枢神经系统分化和发育相关的创伤性脑损伤，包括帕金森病、中风、缺血性脑病、癫痫、阿尔茨海默病、抑郁症、躁郁症、精神分裂症；眼部疾病，如年龄相关性黄斑变性、糖尿病性黄斑水肿或色素性视网膜炎以及与干细胞分化和生长相关的疾病，包括脱发、造血相关疾病和组织再生相关疾病。
• US8921413B2
  申请人：——

  公开号：US8921413B2

  公开（公告）日：2014-12-30
• US9884053B2
  申请人：——

  公开号：US9884053B2

  公开（公告）日：2018-02-06