4-Amino-2-[4-hydroxy-2-(hydroxymethyl)-5-(hydroxymethylamino)-6-methoxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,5-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Amino-2-[4-hydroxy-2-(hydroxymethyl)-5-(hydroxymethylamino)-6-methoxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,5-diol
• 英文别名: 4-amino-2-[4-hydroxy-2-(hydroxymethyl)-5-(hydroxymethylamino)-6-methoxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,5-diol
• 化学式: C₁₄H₂₈N₂O₁₀
• 分子量: 384.38
• InChiKey: KOPNFYWDSXIYEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.8
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  196
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• SUBSTRATE REDUCTION THERAPY
  申请人：The Chancellor, Masters and Scholars of the University of Oxford

  公开号：US20140080769A1

  公开（公告）日：2014-03-20

  The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.
• US9428541B2
  申请人：——

  公开号：US9428541B2

  公开（公告）日：2016-08-30
• [EN] TREATMENT OF MYCOBACTERIAL INFECTION<br/>[FR] TRAITEMENT D'UNE INFECTION MYCOBACTÉRIENNE
  申请人：ISIS INNOVATION

  公开号：WO2016110702A1

  公开（公告）日：2016-07-14

  The invention provides provides a combination comprising a SERCA antagonist and an inhibitor of glycosphingolipid biosynthesis, for use in the treatment of an infection by a pathogenic mycobacterium. The combination may for instance be used to treat tuberculosis.