(3S,6R)-6-[(3S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-propyloxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,6R)-6-[(3S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-propyloxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
• 化学式: C₁₇H₂₉NO₁₁
• 分子量: 423.4
• InChiKey: WPODSWFWTSFGGK-NLFOQLNPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  195
• 氢给体数：
  7
• 氢受体数：
  11

文献信息

• [EN] BIOMATERIALS WITH A SUSTAINABLE SURFACE<br/>[FR] MATIÈRES D'ORIGINE BIOLOGIQUE À SURFACE RENOUVELABLE
  申请人：UNIV MINNESOTA

  公开号：WO2013176739A1

  公开（公告）日：2013-11-28

  Polymeric materials with improved (e.g. continuous) antifouling surfaces. The materials can be incorporated into a variety of materials, including medical devices, microspheres, nanoparticles, and containers. These materials combine amphiphilic copolymer conjugates having hyaluronan as the hydrophilic component, dispersed throughout bulk polymeric biomaterial. The hydrophobic component of the copolymer will have good compatibility with host bulk polymer, enabling excellent dispersion of the copolymer in the bulk, and anchorage for the hydrophilic component at the surface. The hydrophilic hyaluronan segment will spread on the surface of polymers and act as an antifouling layer in an aqueous environment; and the copolymer will dispersed uniformly in the polymer matrix and will not migrate to the surface because of its high molecular weight. Hence, as the bulk polymer degrades, the dispersed HA-amphiphile will become available to "coat" the dynamically evolving biointerface.