(2S)-6-[[3-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethyl]-1,2-dihydrotriazol-5-yl]methyl-[[1-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethyl]triazol-4-yl]methyl]amino]-2-[bis[[1-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethyl]triazol-4-yl]methyl]amino]-N-(6-hydroxyhexyl)hexanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S)-6-[[3-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethyl]-1,2-dihydrotriazol-5-yl]methyl-[[1-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethyl]triazol-4-yl]methyl]amino]-2-[bis[[1-[2-[2-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethyl]triazol-4-yl]methyl]amino]-N-(6-hydroxyhexyl)hexanamide
• 化学式: C₇₂H₁₂₅N₁₉O₃₀
• 分子量: 1736.9
• InChiKey: UIXZJTVYSSJVFV-YJZHFQSDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -10
• 重原子数：
  121
• 可旋转键数：
  57
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  645
• 氢给体数：
  20
• 氢受体数：
  41

文献信息

• [EN] SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS<br/>[FR] COMPOSITIONS DE PETIT ACIDE NUCLÉIQUE INTERFÉRENT (SINA)
  申请人：MERCK SHARP & DOHME

  公开号：WO2013165816A2

  公开（公告）日：2013-11-07

  The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.