(3S,4S,5S,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,4S,5S,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid
• 化学式: C₆H₁₀O₇
• 分子量: 194.14
• InChiKey: AEMOLEFTQBMNLQ-UGPFFVOWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• [EN] CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES<br/>[FR] VACCINS CONJUGUANT UN HYDRATE DE CARBONE ET UN GLYCOLIPIDE
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2013178236A1

  公开（公告）日：2013-12-05

  The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure wherein a carbohydrate antigen is covalently bound to a glycolipid adjuvant. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.