(2S)-2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid;4-oxo-1H-quinoline-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S)-2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid;4-oxo-1H-quinoline-2-carboxylic acid
• 化学式: C20H19N3O7
• 分子量: 413.4
• InChiKey: AGZJLRZBYPLBCK-RGMNGODLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.19
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  193
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• Determination of tryptophan metabolites for assessing liver cell function
  申请人：Ruprecht-Karls-Universität Heidelberg

  公开号：EP2711708A1

  公开（公告）日：2014-03-26

  The present invention relates to a method for assessing damage in cells expressing the tryptophan degradation pathway, comprising (a) determining the amount of tryptophan and /or the amount of at least one tryptophan degradation product in a sample comprising metabolites of said cells expressing the tryptophan degradation pathway, (b) comparing the amount determined in step (a) with a reference amount, (c) thereby determining damage in cells expressing the tryptophan degradation pathway. The present invention further relates to a method for identifying a compound detrimental to cells expressing the tryptophan degradation pathway, and to the use of the amount of tryptophan and / or the amount of at least one tryptophan degradation product in a sample from cells expressing the tryptophan degradation pathway for determining damage in cells expressing the tryptophan degradation pathway and / or for identifying a compound detrimental to cells expressing the tryptophan degradation pathway. The invention also related to a device for assessing damage in cells expressing the tryptophan degradation pathway, to a kit comprising instructions to carry out the method of the present invention, to a method for assessing liver damage and / or impairment of liver function in a subject, and to a method for assessing if treatment of liver damage and / or impairment of liver function is effective in a subject.

  本发明涉及一种评估表达色氨酸降解途径的细胞受损情况的方法，包括(a)确定由表达色氨酸降解途径的细胞的代谢物组成的样品中的色氨酸量和/或至少一种色氨酸降解产物的量；(b)将步骤(a)中确定的量与参考量进行比较；(c)从而确定表达色氨酸降解途径的细胞受损情况。本发明进一步涉及一种鉴定对表达色氨酸降解途径的细胞有害的化合物的方法，以及使用表达色氨酸降解途径的细胞样品中色氨酸的量和/或至少一种色氨酸降解产物的量来确定表达色氨酸降解途径的细胞中的损伤和/或鉴定对表达色氨酸降解途径的细胞有害的化合物。本发明还涉及一种用于评估表达色氨酸降解途径的细胞中的损伤的装置，涉及一种包含实施本发明方法的说明的试剂盒，涉及一种评估受试者肝损伤和/或肝功能损害的方法，以及涉及一种评估受试者肝损伤和/或肝功能损害的治疗是否有效的方法。
• [EN] DETERMINATION OF TRYPTOPHAN METABOLITES FOR ASSESSING LIVER CELL FUNCTION<br/>[FR] DÉTERMINATION DES MÉTABOLITES DU TRYPTOPHANE POUR L'ÉVALUATION DE LA FONCTION DES CELLULES DU FOIE
  申请人：UNIV RUPRECHT KARLS HEIDELBERG

  公开号：WO2014044700A1

  公开（公告）日：2014-03-27

  The present invention relates to a method for assessing damage in cells expressing the tryptophan degradation pathway, comprising (a) determining the amount of tryptophan and / or the amount of at least one tryptophan degradation product in a sample comprising metabolites of said cells expressing the tryptophan degradation pathway, (b) comparing the amount determined in step (a) with a reference amount, (c) thereby determining damage in cells expressing the tryptophan degradation pathway. The present invention further relates to a method for identifying a compound detrimental to cells expressing the tryptophan degradation pathway, and to the use of the amount of tryptophan and / or the amount of at least one tryptophan degradation product in a sample from cells expressing the tryptophan degradation pathway for determining damage in cells expressing the tryptophan degradation pathway and / or for identifying a compound detrimental to cells expressing the tryptophan degradation pathway. The invention also related to a device for assessing damage in cells expressing the tryptophan degradation pathway, to a kit comprising instructions to carry out the method of the present invention, to a method for assessing liver damage and / or impairment of liver function in a subject, and to a method for assessing if treatment of liver damage and / or impairment of liver function is effective in a subject.