6-Aminooxy-2,4,4,6-tetramethylheptan-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-Aminooxy-2,4,4,6-tetramethylheptan-3-one
• 英文别名: 6-aminooxy-2,4,4,6-tetramethylheptan-3-one
• 化学式: C₁₁H₂₃NO₂
• 分子量: 201.31
• InChiKey: HBFNFJGPSPYVTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• FC CONTAINING POLYPEPTIDES WITH ALTERED GLYCOSYLATION AND REDUCED EFFECTOR FUNCTION
  申请人：Genzyme Corporation

  公开号：EP2895513B1

  公开（公告）日：2018-05-23
• [EN] FC CONTAINING POLYPEPTIDES WITH ALTERED GLYCOSYLATION AND REDUCED EFFECTOR FUNCTION<br/>[FR] POLYPEPTIDES CONTENANT FC AYANT UNE GLYCOSYLATION MODIFIÉE ET UNE FONCTION EFFECTRICE RÉDUITE
  申请人：GENZYME CORP

  公开号：WO2014043361A1

  公开（公告）日：2014-03-20

  Provided are binding polypeptides (e.g., antibodies), and drug conjugates thereof, comprising an Fc domain with an altered glycosylation profile and reduced effector function. In particular embodiment, the Fc domain comprises: an asparagine residue at amino acid position 298, according to EU numbering; and a serine or threonine residue at amino acid position 300, according to EU numbering. Also provided are nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.
• [EN] SITE-SPECIFIC GLYCOENGINEERING OF TARGETING MOIETIES<br/>[FR] MODIFICATION DE LA GLYCO-INGÉNIÉRIE DE FRACTIONS DE CIBLAGE SPÉCIFIQUE À UN SITE
  申请人：GENZYME CORP

  公开号：WO2015143091A1

  公开（公告）日：2015-09-24

  The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.