(4R)-4-amino-2-methylheptan-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4R)-4-amino-2-methylheptan-3-one
• 化学式: C₈H₁₇NO
• 分子量: 143.23
• InChiKey: BEDWWNLPJGRTBG-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Methods for treatment or prevention of damage resulting from radiation, trauma or shock
  申请人：SYNEDGEN, INC.

  公开号：US10022393B2

  公开（公告）日：2018-07-17

  Described herein are methods of treating a subject that has been or will be exposed to radiation, trauma or shock, the method comprising identifying a subject that has been or will be exposed to radiation, and treating the subject with a compound that treats, reduces the severity or delays the onset of sepsis or reduces the likelihood of mortality in a subject upon administration of a therapeutically effective amount the compound to the subject.

  本文描述的是治疗已经或将要暴露于辐射、创伤或休克的受试者的方法，该方法包括识别已经或将要暴露于辐射的受试者，并用一种化合物治疗受试者，该化合物可在对受试者施用治疗有效量的化合物后治疗、减轻败血症的严重程度或延迟败血症的发生或降低死亡率的可能性。
• METHODS FOR TREATMENT OR PREVENTION OF DAMAGE RESULTING FROM RADIATION, TRAUMA OR SHOCK
  申请人：SYNEDGEN, INC.

  公开号：US20140080785A1

  公开（公告）日：2014-03-20

  Described herein are methods of treating a subject that has been or will be exposed to radiation, trauma or shock, the method comprising identifying a subject that has been or will be exposed to radiation, and treating the subject with a compound that treats, reduces the severity or delays the onset of sepsis or reduces the likelihood of mortality in a subject upon administration of a therapeutically effective amount the compound to the subject.
• COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：SYNEDGEN, INC.

  公开号：US20170304355A1

  公开（公告）日：2017-10-26

  Described herein are methods for treating or preventing a disease or disorder of the pulmonary system (e.g., cystic fibrosis), respiratory or digestive system in a subject, the methods comprising administering compounds or compositions comprising water soluble polyglucosamine and derivatized polyglucosamine.
• AMINO INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20200339581A1

  公开（公告）日：2020-10-29

  Disclosed are compounds of Formula (I) or salts thereof, wherein G, R1, R5, R7, R8, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.