(3R,4R,5R)-2-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-3,4-dibutoxy-5-(butoxymethyl)oxolan-2-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,4R,5R)-2-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-3,4-dibutoxy-5-(butoxymethyl)oxolan-2-ol
• 化学式: C₂₂H₃₇N₅O₅
• 分子量: 451.6
• InChiKey: TWSMJXJGGAKTTJ-BEBASYGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  32
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20170044206A1

  公开（公告）日：2017-02-16

  A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base 1 , Base 2 , Y, Y a , X a , X a1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3 , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , and R 8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
• [EN] COMPOUNDS AND COMPOSITIONS FOR MODULATING ADENOSINE A3 RECEPTOR ACTIVITY<br/>[FR] COMPOSÉS ET COMPOSITIONS DE MODULATION DE L'ACTIVITÉ DU RÉCEPTEUR ADÉNOSINE A3
  申请人：KAINOS MEDICINE INC

  公开号：WO2014042433A2

  公开（公告）日：2014-03-20

  The present invention provides for Adenosine A3 receptor agonists, and also methods and use of the compounds of the invention, by themselves or in combination with other therapies, for treating a disease, disorder, or condition.
• [EN] COMPOUNDS AND COMPOSITIONS FOR MODULATING HISTONE METHYLTRANSFERASE ACTIVITY<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LA MODULATION DE L'ACTIVITÉ HISTONE MÉTHYLTRANSFÉRASE
  申请人：KAINOS MEDICINE INC

  公开号：WO2014035140A2

  公开（公告）日：2014-03-06

  The invention provides DOT1L inhibitors, and also methods and use of the compounds of the invention, by themselves or in combination with other therapies, for treating a disease, disorder, or condition.