7-[(2S,3S,4R,5R)-3,4-dibutoxy-5-(butoxymethyl)oxolan-2-yl]imidazo[2,1-f][1,2,4]triazin-4-amine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-[(2S,3S,4R,5R)-3,4-dibutoxy-5-(butoxymethyl)oxolan-2-yl]imidazo[2,1-f][1,2,4]triazin-4-amine
• 化学式: C₂₂H₃₇N₅O₄
• 分子量: 435.6
• InChiKey: UBYCGPOVTYVLJH-WCIQWLHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  31
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150274767A1

  公开（公告）日：2015-10-01

  The present invention is directed to 4′-substituted nucleoside derivatives of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.

  本发明涉及式I的4'-取代核苷衍生物及其在抑制HIV逆转录酶、预防HIV感染、治疗HIV感染以及预防、治疗和延缓AIDS和/或ARC的发病或进展中的应用。
• US9777035B2
  申请人：——

  公开号：US9777035B2

  公开（公告）日：2017-10-03
• [EN] COMPOUNDS AND COMPOSITIONS FOR MODULATING ADENOSINE A3 RECEPTOR ACTIVITY<br/>[FR] COMPOSÉS ET COMPOSITIONS DE MODULATION DE L'ACTIVITÉ DU RÉCEPTEUR ADÉNOSINE A3
  申请人：KAINOS MEDICINE INC

  公开号：WO2014042433A2

  公开（公告）日：2014-03-20

  The present invention provides for Adenosine A3 receptor agonists, and also methods and use of the compounds of the invention, by themselves or in combination with other therapies, for treating a disease, disorder, or condition.
• [EN] COMPOUNDS AND COMPOSITIONS FOR MODULATING HISTONE METHYLTRANSFERASE ACTIVITY<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LA MODULATION DE L'ACTIVITÉ HISTONE MÉTHYLTRANSFÉRASE
  申请人：KAINOS MEDICINE INC

  公开号：WO2014035140A2

  公开（公告）日：2014-03-06

  The invention provides DOT1L inhibitors, and also methods and use of the compounds of the invention, by themselves or in combination with other therapies, for treating a disease, disorder, or condition.
• [EN] 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS<br/>[FR] DÉRIVÉS NUCLÉOSIDIQUES 4'-SUBSTITUÉS UTILISÉS COMME INHIBITEURS DE LA TRANSCRIPTASE INVERSE DU VIH
  申请人：MERCK SHARP & DOHME

  公开号：WO2015148746A1

  公开（公告）日：2015-10-01

  The present invention is directed to 4'-substituted nucleoside derivatives of Formula I (Formula I), and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC.