2',6'-dimethoxy-2,4,6-triethoxychalcone | 944447-09-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2',6'-dimethoxy-2,4,6-triethoxychalcone
• 英文别名: (E)-2',6'-dimethoxy-2,4,6-triethoxychalcone；(E)-1-(2,6-dimethoxyphenyl)-3-(2,4,6-triethoxyphenyl)prop-2-en-1-one
• CAS: 944447-09-0
• 化学式: C₂₃H₂₈O₆
• 分子量: 400.472
• InChiKey: ZENTZXGFZHRONN-OUKQBFOZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,6-二甲氧基苯乙酮 、 2,4,6-三乙氧基苯甲醛 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 以10%的产率得到2',6'-dimethoxy-2,4,6-triethoxychalcone
  参考文献：
  名称：

  Antimitotic and Antiproliferative Activities of Chalcones: Forward Structure–Activity Relationship

  摘要：

  A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of I I human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation.

  DOI：

  10.1021/jm0708331

文献信息

• Novel Chalcone Derivatives With Antimitotic Activity
  申请人：Boumendjel Ahcene

  公开号：US20090182058A1

  公开（公告）日：2009-07-16

  The present invention relates to novel chalcone derivatives of formula (I): wherein X, Y, Z, W, RI, R2, R3, R4 and R5 are as defined, said derivatives having antimitotic activity, as well as to pharmaceutical compositions containing such compounds and to their use for making drugs.

  本发明涉及具有抗有丝分裂活性的新型葵花素衍生物的公式(I)：其中X、Y、Z、W、RI、R2、R3、R4和R5如定义所述，以及含有这种化合物的药物组合物，以及其用于制备药物的用途。
• [EN] NOVEL CHALCONE DERIVATIVES WITH ANTIMITOTIC ACTIVITY<br/>[FR] NOUVEAUX DERIVES DE CHALCONE A ACTIVITE ANTIMITOTIQUE
  申请人：UNIV CLAUDE BERNARD LYON

  公开号：WO2007083060A2

  公开（公告）日：2007-07-26

  [EN] The present invention relates to novel chalcone derivatives of formula (I): in which X, Y, Z, W, R1, R2, R3, R4 and R5 are as defined, wherein said derivatives have antimitotic activity, and also to the pharmaceutical compositions containing such compounds and to the use thereof for the manufacture of medicaments.
  [FR] La présente invention concerne de nouveaux dérivés de chalcone de formule (I) : dans laquelle X, Y, Z, W, R1, R2, R3 R4 et R5 sont tels que définis, lesdits dérivés présentant une activité antimitotique, ainsi que les compositions pharmaceutiques contenant de tels composés et leur utilisation pour la fabrication de médicaments.
• Antimitotic and Antiproliferative Activities of Chalcones: Forward Structure–Activity Relationship
  作者：Ahcène Boumendjel、Julien Boccard、Pierre-Alain Carrupt、Edwige Nicolle、Madeleine Blanc、Annabelle Geze、Luc Choisnard、Denis Wouessidjewe、Eva-Laure Matera、Charles Dumontet

  DOI：10.1021/jm0708331

  日期：2008.4.1

  A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of I I human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation.