2-(2-Fluoroethoxy)pyridine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-Fluoroethoxy)pyridine
• 英文别名: 2-(2-fluoroethoxy)pyridine
• 化学式: C₇H₈FNO
• 分子量: 141.14
• InChiKey: KSSZPTYZLMBNBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20150158875A1

  公开（公告）日：2015-06-11

  The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.

  本发明涉及取代的氮杂双环咪唑衍生物、含有它们的药物组合物以及它们在治疗由TRP M8调节的疾病和病症中的应用，例如炎症性疼痛、炎症性过敏症、炎症性过敏性疾病、神经病理性疼痛、神经性冷痛觉、炎症性体表过敏症、炎症性内脏过敏症、由寒冷加重的心血管疾病和由寒冷加重的肺部疾病。
• PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS
  申请人：SANOFI

  公开号：EP2870156B1

  公开（公告）日：2020-06-17
• 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP3004107B1

  公开（公告）日：2017-05-10
• SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
  申请人：Janssen Pharmaceutica NV

  公开号：US20190055257A1

  公开（公告）日：2019-02-21

  The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (“mGluR2”). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.
• US8680098B2
  申请人：——

  公开号：US8680098B2

  公开（公告）日：2014-03-25