5-溴-4-氯-n-(4-甲氧基苄基)噻唑-2-胺 | 944805-53-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 5-溴-4-氯-n-(4-甲氧基苄基)噻唑-2-胺
• 中文别名: 5-溴-4-氯-N-(4-甲氧基苄基)噻唑-2-胺
• 英文名称: 5-bromo-4-chloro-N-(4-methoxybenzyl)thiazol-2-amine
• 英文别名: 5-bromo-4-chloro-N-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-amine
• CAS: 944805-53-2
• 化学式: C₁₁H₁₀BrClN₂OS
• 分子量: 333.636
• InChiKey: NAJLOTMGFHGMQA-UHFFFAOYSA-N

物化性质

• 沸点：
  454.0±55.0 °C(Predicted)
• 密度：
  1.631±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  62.4
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2934100090

反应信息

• 作为反应物：
  描述：

  5-溴-4-氯-n-(4-甲氧基苄基)噻唑-2-胺 在 4-二甲氨基吡啶 、 三乙胺 作用下， 生成 tert-butyl (5-bromo-4-chlorothiazol-2-yl)(4-methoxybenzyl)carbamate
  参考文献：
  名称：

  PYRIDINE N-OXIDE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS

  摘要：

  The present invention is directed to pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.

  公开号：

  US20230091768A1
• 作为产物：
  描述：

  2,5-二溴-4-氯-1,3-噻唑 、 4-甲氧基苄胺 生成 5-溴-4-氯-n-(4-甲氧基苄基)噻唑-2-胺
  参考文献：
  名称：

  PYRIDINE N-OXIDE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS

  摘要：

  The present invention is directed to pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.

  公开号：

  US20230091768A1

文献信息

• Thiazole compounds and methods of use
  申请人：Zeng Qingping

  公开号：US20070173506A1

  公开（公告）日：2007-07-26

  The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

  该发明涉及Formula I和Formula II的噻唑化合物及其组合物，用于治疗由蛋白激酶B（PKB）介导的疾病，其中变量具有此处提供的定义。该发明还涉及这种噻唑化合物及其组合物在治疗与异常细胞生长、癌症、炎症和代谢紊乱相关的疾病状态中的治疗用途。
• EP1981884A2
  申请人：——

  公开号：EP1981884A2

  公开（公告）日：2008-10-22
• THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS
  申请人：Amgen, Inc

  公开号：EP1981884B1

  公开（公告）日：2012-06-13
• US7514566B2
  申请人：——

  公开号：US7514566B2

  公开（公告）日：2009-04-07
• US8084479B2
  申请人：——

  公开号：US8084479B2

  公开（公告）日：2011-12-27