(2R,3R,4R,5S)-3,4,5-trihydroxy-6-oxooxane-2-carbaldehyde

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4R,5S)-3,4,5-trihydroxy-6-oxooxane-2-carbaldehyde
• 化学式: C₆H₈O₆
• 分子量: 176.12
• InChiKey: JBQGSJDKHSBLDG-KLVWXMOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF
  申请人：Synthetic Genomics, Inc.

  公开号：EP2898083A1

  公开（公告）日：2015-07-29
• US9506090B2
  申请人：——

  公开号：US9506090B2

  公开（公告）日：2016-11-29
• US9528133B2
  申请人：——

  公开号：US9528133B2

  公开（公告）日：2016-12-27
• [EN] COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRODUCTION DE PRODUITS CHIMIQUES ET DE LEURS DÉRIVÉS
  申请人：SYNTHETIC GENOMICS INC

  公开号：WO2014047510A1

  公开（公告）日：2014-03-27

  The present invention provides methods for producing a product of one or more enzymatic pathways. The methods include both enzymatic and chemical conversions as steps. Various pathways are provided for converting glucose into 5-dehdyro-4-deoxyglucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency.
• [EN] COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRODUCTION DE PRODUITS CHIMIQUES ET DE DÉRIVÉS DE CEUX-CI
  申请人：SYNTHETIC GENOMICS INC

  公开号：WO2015143381A2

  公开（公告）日：2015-09-24

  The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Various pathways are also provided for converting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency. Additional products that can be produce include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or pathways of the invention.