Methyl 3-[2-[2-[2-[2,6-bis(hydroxymethyl)pyridin-4-yl]oxyethoxy]ethoxy]ethoxy]propanoate | 1111715-88-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methyl 3-[2-[2-[2-[2,6-bis(hydroxymethyl)pyridin-4-yl]oxyethoxy]ethoxy]ethoxy]propanoate
• CAS: 1111715-88-8
• 化学式: C₁₇H₂₇NO₈
• 分子量: 373.403
• InChiKey: RFHSCMBIHCPFEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  diethyl 4-[2-[2-[2-(3-methoxy-3-oxopropoxy)ethoxy]ethoxy]ethoxy]pyridine-2,6-dicarboxylate 在 sodium tetrahydroborate 作用下， 生成 Methyl 3-[2-[2-[2-[2,6-bis(hydroxymethyl)pyridin-4-yl]oxyethoxy]ethoxy]ethoxy]propanoate
  参考文献：
  名称：

  [EN] CYTOTOXIC BENZODIAZEPINE DERIVATIVES
  [FR] DÉRIVÉS DE BENZODIAZÉPINE CYTOTOXIQUE

  摘要：

  本发明涉及具有抗增殖活性的新型苯二氮平衍生物，更具体地涉及公式（I）-（VII）的新型苯二氮平化合物。本发明还提供了与细胞结合剂连接的苯二氮平化合物的共轭物。本发明还提供了使用本发明的化合物或共轭物抑制异常细胞生长或治疗哺乳动物增殖性疾病的组合物和方法。

  公开号：

  WO2014031566A1

文献信息

• CYTOTOXIC AGENTS COMPRISING NEW TOMAYMYCIN DERIVATIVES AND THEIR THERAPEUTIC USE
  申请人：Bouchard Hervé

  公开号：US20100316656A1

  公开（公告）日：2010-12-16

  The invention relates to novel tomaymicine derivatives comprising a linker. It also relates to the conjugate molecules that comprise one or more of said tomaymicine derivatives covalently linked to a cell binding agent through a linking group that is present on the linker of the tomaymycin derivative. It also relates to the preparation of the tomaymicine derivatives and of the conjugate molecules.

  本发明涉及一种新型的含有连接器的托马伊霉素衍生物。它还涉及到包含一种或多种上述托马伊霉素衍生物的共轭分子，该共轭分子通过位于托马伊霉素衍生物连接器上的连接基与细胞结合剂共价连接。它还涉及到托马伊霉素衍生物和共轭分子的制备。
• US8404678B2
  申请人：——

  公开号：US8404678B2

  公开（公告）日：2013-03-26
• [EN] CYTOTOXIC AGENTS COMPRISING NEW TOMAYMYCIN DERIVATIVES AND THEIR THERAPEUTIC USE<br/>[FR] AGENTS CYTOTOXIQUES COMPRENANT DE NOUVEAUX DÉRIVÉS DE LA TOMAYMYCINE ET LEUR UTILISATION THÉRAPEUTIQUE
  申请人：SANOFI AVENTIS

  公开号：WO2009016516A2

  公开（公告）日：2009-02-05

  The invention relates to novel tomaymicine derivatives comprising a linker. It also relates to the conjugate molecules that comprise one or more of said tomaymicine derivatives covalently linked to a cell binding agent through a linking group that is present on the linker of the tomaymycin derivative. It also relates to the preparation of the tomaymicine derivatives and of the conjugate molecules.
• [EN] CYTOTOXIC BENZODIAZEPINE DERIVATIVES<br/>[FR] DÉRIVÉS DE BENZODIAZÉPINE CYTOTOXIQUE
  申请人：IMMUNOGEN INC

  公开号：WO2014031566A1

  公开（公告）日：2014-02-27

  The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

  本发明涉及具有抗增殖活性的新型苯二氮平衍生物，更具体地涉及公式（I）-（VII）的新型苯二氮平化合物。本发明还提供了与细胞结合剂连接的苯二氮平化合物的共轭物。本发明还提供了使用本发明的化合物或共轭物抑制异常细胞生长或治疗哺乳动物增殖性疾病的组合物和方法。