methyl 3-[2-[anilino-[[(2R,3R,4R,5S)-4-fluoro-3-hydroxy-4,5-dimethyloxolan-2-yl]methoxy]phosphoryl]oxyethylsulfanyl]-2,2-dimethyl-3-oxopropanoate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 3-[2-[anilino-[[(2R,3R,4R,5S)-4-fluoro-3-hydroxy-4,5-dimethyloxolan-2-yl]methoxy]phosphoryl]oxyethylsulfanyl]-2,2-dimethyl-3-oxopropanoate
• 化学式: C₂₁H₃₁FNO₈PS
• 分子量: 507.5
• InChiKey: JIAKJDFVYFFBRI-WZQCRNPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  33
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Esters and Malonates of SATE Prodrugs
  申请人：IDENIX PHARMACEUTICALS, INC.

  公开号：US20140086873A1

  公开（公告）日：2014-03-27

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, provided herein are compounds according to Formula 1001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein Base, Y, Z, A, R C and R D are as described herein.
• US9192621B2
  申请人：——

  公开号：US9192621B2

  公开（公告）日：2015-11-24