2-(2,4,4-Trimethylpentan-2-yloxy)ethanol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2,4,4-Trimethylpentan-2-yloxy)ethanol
• 英文别名: 2-(2,4,4-trimethylpentan-2-yloxy)ethanol
• 化学式: C₁₀H₂₂O₂
• 分子量: 174.28
• InChiKey: YRLBQRBYAJBMAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• HOLLOW FIBER MEMBRANE FOR BLOOD TREATMENT AND HOLLOW FIBER MEMBRANE-TYPE BLOOD TREATMENT APPARATUS
  申请人：Asahi Kasei Medical Co., Ltd.

  公开号：EP2719408A1

  公开（公告）日：2014-04-16

  [Problem to be Solved] It is intended to obtain a hollow fiber membrane for blood processing that has high membrane performance, can reduce leak misdetection, is excellent in antioxidative performance and blood compatibility, carries a low risk of hydrophilic polymer elution or a leak from hollow fibers, is easy to prime, and has highly stable permeability in a harsh environment. [Solution] The present invention provides a hollow fiber membrane for blood processing, containing a hydrophilic polymer, a polysulfone-based resin, and a fat-soluble vitamin, wherein a content A of the hydrophilic polymer, which is a mass ratio of the hydrophilic polymer to a total mass of the hydrophilic polymer and the polysulfone-based resin in a whole of the hollow fiber membrane for blood processing, is 3% by mass or larger and 10% by mass or smaller, an abundance ratio B of the hydrophilic polymer, which is a mass ratio of the hydrophilic polymer to the total mass of the hydrophilic polymer and the polysulfone-based resin in an inner surface of the hollow fiber membrane for blood processing, is 35% by mass or larger and 50% by mass or smaller, and an abundance of the fat-soluble vitamin in an entire surface of the hollow fiber membrane for blood processing is 0.5 mg or larger and 25 mg or smaller based on 1 g of the hollow fiber membrane.

  [有待解决的问题］ 旨在获得一种用于血液处理的中空纤维膜，该膜具有较高的膜性能，可减少泄漏误检，抗氧化性能和血液相容性优异，亲水性聚合物洗脱或中空纤维泄漏的风险较低，易于填料，并且在恶劣环境中具有高度稳定的渗透性。 [解决方案］ 本发明提供了一种用于血液处理的中空纤维膜，它含有亲水性聚合物、聚砜基树脂和脂溶性维生素，其中 亲水性聚合物的含量 A，即亲水性聚合物与血液处理用中空纤维膜整体中亲水性聚合物和聚砜基树脂总质量的质量比，大于等于 3%，小于等于 10%、 亲水性聚合物的丰度比 B（即血液处理用中空纤维膜内表面中亲水性聚合物与亲水性聚合物和聚砜基树脂总质量的质量比）为 35% （以质量为单位）或更大，50% （以质量为单位）或更小，以及 以 1 克中空纤维膜为基准，血液处理用中空纤维膜整个表面中脂溶性维生素的丰度为 0.5 毫克或更大，25 毫克或更小。