4-[1-Oxo-1-(4-oxocyclohexa-1,5-dien-1-yl)butan-2-yl]cyclohexa-2,4-dien-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[1-Oxo-1-(4-oxocyclohexa-1,5-dien-1-yl)butan-2-yl]cyclohexa-2,4-dien-1-one
• 英文别名: 4-[1-oxo-1-(4-oxocyclohexa-1,5-dien-1-yl)butan-2-yl]cyclohexa-2,4-dien-1-one
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.3
• InChiKey: PCXQOTLKUADIEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  51.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] SULFESTROL FOR TREATING CANCER<br/>[FR] SULFESTROL POUR LE TRAITEMENT DU CANCER
  申请人：CHAMAELEO PHARMA BVBA

  公开号：WO2014060364A1

  公开（公告）日：2014-04-24

  The invention relates to the use of Sulfestrol (diethylstilbestrol sulfate) in a method of curative or palliative treatment of cancer in a mammal. The inventors have unexpectedly found that Sulfestrol can suitably be employed as an effective drug in the treatment of cancer in mammals. The inventors have further discovered that Sulfestrol can be administered even in high dosages without giving rise to serious side effects. Besides the clinical use of Sulfestrol the present invention also relates to oral dosage units comprising Sulfestrol and to sterile liquids for intravenous administration that comprise Sulfestrol.

  本发明涉及在哺乳动物中使用硫雌醇（二乙基雌甾醇硫酸酯）进行治疗或缓解癌症的方法。发明人意外地发现硫雌醇可以作为治疗哺乳动物癌症的有效药物。发明人进一步发现，即使在高剂量下，硫雌醇也可以被使用而不会产生严重的副作用。除了硫雌醇的临床使用外，本发明还涉及包含硫雌醇的口服剂量单位和包含硫雌醇的静脉注射用无菌液体。
• SULFESTROL FOR TREATING CANCER
  申请人：CHAMAELEO PHARMA BVBA

  公开号：US20150283108A1

  公开（公告）日：2015-10-08

  The invention relates to the use of Sulfestrol (diethylstilbestrol sulfate) in a method of curative or palliative treatment of cancer in a mammal. The inventors have unexpectedly found that Sulfestrol can suitably be employed as an effective drug in the treatment of cancer in mammals. The inventors have further discovered that Sulfestrol can be administered even in high dosages without giving rise to serious side effects. Besides the clinical use of Sulfestrol the present invention also relates to oral dosage units comprising Sulfestrol and to sterile liquids for intravenous administration that comprise Sulfestrol.

  本发明涉及使用硫酸二乙基雌苯酚（Sulfestrol）治疗哺乳动物癌症的治疗或缓解方法。发明人意外地发现，Sulfestrol可以作为治疗哺乳动物癌症的有效药物。发明人还发现，即使以高剂量给予Sulfestrol，也不会引起严重的副作用。除了Sulfestrol的临床应用外，本发明还涉及包含Sulfestrol的口服剂量单位和含有Sulfestrol的静脉注射用无菌液体。