[(2R,3R,4S)-2,3,4,6-tetrahydroxy-5-oxohexyl] [(2R,3S,4R,5R)-3,4,5-trihydroxy-1-oxo-6-phosphonooxyhexan-2-yl] hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3R,4S)-2,3,4,6-tetrahydroxy-5-oxohexyl] [(2R,3S,4R,5R)-3,4,5-trihydroxy-1-oxo-6-phosphonooxyhexan-2-yl] hydrogen phosphate
• 化学式: C₁₂H₂₄O₁₇P₂
• 分子量: 502.26
• InChiKey: HRWJGGVNGPLMKD-HTWMRFIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.9
• 重原子数：
  31
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  298
• 氢给体数：
  10
• 氢受体数：
  17

文献信息

• SUPPORT OF NUTRITIONAL NEEDS OF HUMAN AND OTHER PATIENTS
  申请人：Run Them Sweet LLC

  公开号：EP3505167A1

  公开（公告）日：2019-07-03

  Systems, techniques, and methods for estimating the metabolic state or flux, e.g. the body energy state (BES) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.

  本文公开了用于估算患者新陈代谢状态或通量（例如体能状态（BES））的系统、技术和方法。BES 可以深入了解患者的营养需求，从而对患者进行精细的血糖控制。本发明公开了估算部分葡萄糖生成的系统和方法。本发明还公开了估算和定位患者血液乳酸浓度的系统和方法，既可作为目标本身，也可作为估算和定位患者部分葡萄糖生成葡萄糖生成的中间步骤。本发明还公开了营养支持方法和配方。本发明适用于任何类型的病人，包括那些受伤的病人，如脑外伤病人、病人或患有其他对代谢系统造成压力的疾病的病人。
• METHODS AND COMPOSITIONS FOR AFFECTING THE FLAVOUR AND AROMA PROFILE OF CONSUMABLES
  申请人：Impossible Foods Inc.

  公开号：EP4104682A2

  公开（公告）日：2022-12-21

  This document relates to food products containing highly conjugated heterocyclic rings complexed to an iron ion and one or more flavor precursors, and using such food products to modulate the flavor and/or aroma profile of other foods. The food products described herein can be prepared in various ways and can be formulated to be free of animal products.

  本文涉及含有与铁离子和一种或多种风味前体络合的高度共轭杂环的食品，以及使用此类食品来调节其他食品的风味和/或香气特征。本文所述食品可以多种方式制备，并可配制成不含动物产品的食品。
• Systems and methods for monitoring of fractional gluconeogenesis and targeting of fractional gluconeogenesis via nutritional support
  申请人：Run Them Sweet LLC

  公开号：US10010104B2

  公开（公告）日：2018-07-03

  Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.

  本文公开了用于估算患者代谢状态或通量（例如体能状态（BES））的系统、技术和方法。BES 可以深入了解患者的营养需求，从而对患者进行精细的血糖控制。本发明公开了估算部分葡萄糖生成的系统和方法。本发明还公开了估算和定位患者血液乳酸浓度的系统和方法，既可作为目标本身，也可作为估算和定位患者部分葡萄糖生成葡萄糖生成的中间步骤。本发明还公开了营养支持方法和配方。本发明适用于任何类型的病人，包括那些受伤的病人，如脑外伤病人、病人或患有其他对代谢系统造成压力的疾病的病人。
• Systems and methods for monitoring of blood lactate and targeting of blood lactate via nutritional support
  申请人：Run Them Sweet LLC

  公开号：US10088470B2

  公开（公告）日：2018-10-02

  Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.

  本文公开了用于估算患者新陈代谢状态或通量（例如体能状态（BES））的系统、技术和方法。BES 可以深入了解患者的营养需求，从而对患者进行精细的血糖控制。本发明公开了估算部分葡萄糖生成的系统和方法。本发明还公开了估算和定位患者血液乳酸浓度的系统和方法，既可作为目标本身，也可作为估算和定位患者部分葡萄糖生成葡萄糖生成的中间步骤。本发明还公开了营养支持方法和配方。本发明适用于任何类型的病人，包括那些受伤的病人，如脑外伤病人、病人或患有其他对代谢系统造成压力的疾病的病人。
• Continuous monitoring of blood lactate and ongoing targeting of blood lactate via nutritional support
  申请人：Run Them Sweet LLC

  公开号：US10571459B2

  公开（公告）日：2020-02-25

  Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis. The invention also discloses systems and methods for estimating and targeting patient blood lactate concentration, both as a target itself and as an intermediate step to estimating and targeting patient fractional gluconeogenesis glucose production. Nutritional support methods and formulations are also disclosed. The invention is suitable for any sort of patient, including those who are injured, such as with traumatic brain injury, ill, or have other conditions that stress the metabolic system.

  本文公开了用于估算患者代谢状态或通量（例如体能状态（BES））的系统、技术和方法。BES 可以深入了解患者的营养需求，从而对患者进行精细的血糖控制。本发明公开了估算部分葡萄糖生成的系统和方法。本发明还公开了估算和定位患者血液乳酸浓度的系统和方法，既可作为目标本身，也可作为估算和定位患者部分葡萄糖生成葡萄糖生成的中间步骤。本发明还公开了营养支持方法和配方。本发明适用于任何类型的病人，包括那些受伤的病人，如脑外伤病人、病人或患有其他对代谢系统造成压力的疾病的病人。