7-Sulfamoylheptanoic acid | 860315-16-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-Sulfamoylheptanoic acid
• CAS: 860315-16-8
• 化学式: C₇H₁₅NO₄S
• mdl: MFCD24493867
• 分子量: 209.266
• InChiKey: QZTOPAGRUAPHBS-UHFFFAOYSA-N

物化性质

• 沸点：
  417.7±47.0 °C(Predicted)
• 密度：
  1.280±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-Sulfamoylheptanoic acid 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 1-羟基苯并三唑一水物 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N'-羰基二咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent

  摘要：

  A series of suberoylanilide hydroxamic acid (SAHA)-based non-hydroxamates was designed, synthesized, and evaluated for their histone deacetylase (HDAC) inhibitory activity. Among these, methyl sulfoxide 15 inhibited HDACs in enzyme assays and caused hyperacetylation of histone H4 while not inducing the accumulation of acetylated alpha-tubulin in HCT116 cells. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.04.002
• 作为产物：
  描述：

  7-溴庚酸乙酯 在 4-二甲氨基吡啶 、 ammonium hydroxide 、 sodium hydroxide 、 sodium sulfite 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 8.0h， 生成 7-Sulfamoylheptanoic acid
  参考文献：
  名称：

  Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent

  摘要：

  A series of suberoylanilide hydroxamic acid (SAHA)-based non-hydroxamates was designed, synthesized, and evaluated for their histone deacetylase (HDAC) inhibitory activity. Among these, methyl sulfoxide 15 inhibited HDACs in enzyme assays and caused hyperacetylation of histone H4 while not inducing the accumulation of acetylated alpha-tubulin in HCT116 cells. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.04.002

文献信息

• Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent
  作者：Takayoshi Suzuki、Azusa Matsuura、Akiyasu Kouketsu、Shinya Hisakawa、Hidehiko Nakagawa、Naoki Miyata

  DOI：10.1016/j.bmc.2005.04.002

  日期：2005.7

  A series of suberoylanilide hydroxamic acid (SAHA)-based non-hydroxamates was designed, synthesized, and evaluated for their histone deacetylase (HDAC) inhibitory activity. Among these, methyl sulfoxide 15 inhibited HDACs in enzyme assays and caused hyperacetylation of histone H4 while not inducing the accumulation of acetylated alpha-tubulin in HCT116 cells. (c) 2005 Elsevier Ltd. All rights reserved.